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    NAGK N-acetyl-l-glutamate kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824923, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NAGK
    Official Full Name
    N-acetyl-l-glutamate kinase
    Primary source
    TAIR:AT3G57560
    Locus tag
    AT3G57560
    See related
    Araport:AT3G57560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    N-acetyl-l-glutamate kinase
    Summary
    encodes a N-acetylglutamate kinase, involved in arginine biosynthesis
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    Genomic context

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    See NAGK in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (21310825..21312378, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Remorin family protein Neighboring gene guanylate kinase Neighboring gene ARM repeat superfamily protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana. Huang J, et al. J Integr Plant Biol, 2017 Sep. PMID 28294536
    2. A widespread glutamine-sensing mechanism in the plant kingdom. Chellamuthu VR, et al. Cell, 2014 Nov 20. PMID 25416954
    3. Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase. Feria Bourrellier AB, et al. Biochem Biophys Res Commun, 2009 Oct 2. PMID 19631611
    4. N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control. Beez S, et al. J Mol Biol, 2009 Jun 19. PMID 19409905
    5. Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. Mizuno Y, et al. J Biol Chem, 2007 Dec 7. PMID 17913711

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functions with arginine to regulate gametophyte function and embryo development
      Title: Acetylglutamate kinase is required for both gametophyte function and embryo development in Arabidopsis thaliana.
    2. These results reveal a complex metabolic control of the PII interaction with NAGK in the chloroplast stroma of higher plants.
      Title: Metabolite regulation of the interaction between Arabidopsis thaliana PII and N-acetyl-l-glutamate kinase.
    3. Data show that the non-conserved C-terminus of Synechococcus elongatus N-acetylglutamate kinase (NAGK) enhances arginine inhibition and holds most of the differences between S. elongatus and Arabidopsis NAGK with respect to arginine sensitivity.
      Title: N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115616.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetylglutamate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within arginine biosynthetic process via ornithine TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    N-acetyl-l-glutamate kinase
    NP_191315.1
    • N-acetyl-l-glutamate kinase (NAGK); FUNCTIONS IN: acetylglutamate kinase activity; INVOLVED IN: arginine biosynthetic process via ornithine, arginine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: N-acetylglutamate kinase (InterPro:IPR011148), Glutamate 5-kinase (InterPro:IPR001057), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Acetylglutamate kinase (InterPro:IPR004662); BEST Arabidopsis thaliana protein match is: N-acetyl-l-glutamate synthase 2 (TAIR:AT4G37670.2); Has 9387 Blast hits to 9387 proteins in 2227 species: Archae - 281; Bacteria - 6131; Metazoa - 9; Fungi - 140; Plants - 140; Viruses - 0; Other Eukaryotes - 2686 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21310825..21312378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115616.3 → NP_191315.1  N-acetyl-l-glutamate kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA25, Q9SCL7
      UniProtKB/TrEMBL
      A0A178V7F4, A0A5S9XLX7, A0A654FIN6
      Conserved Domains (1) summary
      PLN02512
      Location:39 → 347
      PLN02512; acetylglutamate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SCL7.1

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