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    LPAT2 lysophosphatidyl acyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824934, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LPAT2
    Official Full Name
    lysophosphatidyl acyltransferase 2
    Primary source
    TAIR:AT3G57650
    Locus tag
    AT3G57650
    See related
    Araport:AT3G57650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    lysophosphatidyl acyltransferase 2
    Summary
    Encodes an endoplasmic reticulum localized protein with lysophosphatidyl acyltransferase activity.
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    Genomic context

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    See LPAT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (21349383..21353193)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene nuclear RNA polymerase A1 Neighboring gene ncRNA Neighboring gene C2H2-type zinc finger family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced root growth in phosphate-starved Arabidopsis by stimulating de novo phospholipid biosynthesis through the overexpression of LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE 2 (LPAT2). Angkawijaya AE, et al. Plant Cell Environ, 2017 Sep. PMID 28548242
    2. Ubiquitous and endoplasmic reticulum-located lysophosphatidyl acyltransferase, LPAT2, is essential for female but not male gametophyte development in Arabidopsis. Kim HU, et al. Plant Cell, 2005 Apr. PMID 15772283, Free PMC Article
    3. Identification of Arabidopsis GPAT9 (At5g60620) as an Essential Gene Involved in Triacylglycerol Biosynthesis. Shockey J, et al. Plant Physiol, 2016 Jan. PMID 26586834, Free PMC Article
    4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings propose a revised model of membrane lipid remodelling, in which de novo phospholipid biosynthesis mediated by LPAT2 contributes significantly to root development under phosphate starvation.
      Title: Enhanced root growth in phosphate-starved Arabidopsis by stimulating de novo phospholipid biosynthesis through the overexpression of LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE 2 (LPAT2).
    2. AtLPAT2, encodes the ubiquitous, abundant, and ER-located LPAT. It is essential for female but not male gametophyte development [LAPT2]
      Title: Ubiquitous and endoplasmic reticulum-located lysophosphatidyl acyltransferase, LPAT2, is essential for female but not male gametophyte development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115625.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidyl acyltransferase 2
    NP_567052.1
    • lysophosphatidyl acyltransferase 2 (LPAT2); FUNCTIONS IN: 1-acylglycerol-3-phosphate O-acyltransferase activity; INVOLVED IN: metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipid/glycerol acyltransferase (InterPro:IPR002123); BEST Arabidopsis thaliana protein match is: lysophosphatidyl acyltransferase 3 (TAIR:AT1G51260.1); Has 1646 Blast hits to 1643 proteins in 516 species: Archae - 0; Bacteria - 639; Metazoa - 536; Fungi - 213; Plants - 138; Viruses - 2; Other Eukaryotes - 118 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21349383..21353193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115625.4 → NP_567052.1  lysophosphatidyl acyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG50, Q9SVX9
      UniProtKB/TrEMBL
      A0A5S9XLP8, A0A654FIP7, Q147Q7
      Conserved Domains (1) summary
      PLN02380
      Location:1 → 375
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LG50.2

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