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    TBP1 telomeric DNA binding protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831227, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TBP1
    Official Full Name
    telomeric DNA binding protein 1
    Primary source
    TAIR:AT5G13820
    Locus tag
    AT5G13820
    See related
    Araport:AT5G13820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBP-1; ATBP1; ATTBP1; H-PROTEIN PROMOTE; HPPBF-1; MAC12.23; MAC12_23; telomeric DNA binding protein 1
    Summary
    Encodes a protein that specifically binds plant telomeric DNA repeats. It has a single Myb telomeric DNA-binding domain in C-terminus that prefers the sequence TTTAGGG.
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    Genomic context

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    See TBP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (4460840..4464737)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pheophytinase Neighboring gene Glutaredoxin family protein Neighboring gene uncharacterized protein Neighboring gene FtsJ-like methyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding. Hwang MG, et al. Nucleic Acids Res, 2007. PMID 17272298, Free PMC Article
    2. Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1). Hwang MG, et al. FEBS Lett, 2001 Aug 10. PMID 11513850
    3. Specific association of a small protein with the telomeric DNA-protein complex during the onset of leaf senescence in Arabidopsis thaliana. Zentgraf U, et al. Plant Mol Biol, 2000 Feb. PMID 10798613
    4. DNA-binding domain of AtTRB2 reveals unique features of a single Myb histone protein family that binds to both Arabidopsis- and human-type telomeric DNA sequences. Lee WK, et al. Mol Plant, 2012 Nov. PMID 22859734
    5. Interaction between the Arabidopsis thaliana heat shock transcription factor HSF1 and the TATA binding protein TBP. Reindl A, et al. FEBS Lett, 1998 Oct 9. PMID 9801140

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified a number of DNA binding proteins each containing a single Myb domain that included the ALWAYS EARLY proteins AtALY2 and AtALY3, and two telomere binding proteins AtTBP1 and AtTRP2/TRFL1 as SNL1 partners
      Title: PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors.
    2. Results suggest that AtTBP1 is involved in the telomere length mechanism in A. thaliana and that the Myb-extension domain of AtTBP1 may stabilize plant telomeric DNA binding.
      Title: Arabidopsis thaliana telomeric DNA-binding protein 1 is required for telomere length homeostasis and its Myb-extension domain stabilizes plant telomeric DNA binding.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343296.1
    NM_121385.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within telomere maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    telomeric DNA binding protein 1
    NP_196886.1
    • telomeric DNA binding protein 1 (TBP1); FUNCTIONS IN: DNA binding, double-stranded telomeric DNA binding; INVOLVED IN: telomere maintenance; LOCATED IN: chromosome, telomeric region, nucleus; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Ubiquitin supergroup (InterPro:IPR019955), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: TRF-like 9 (TAIR:AT3G12560.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4460840..4464737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121385.5 → NP_196886.1  telomeric DNA binding protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81375, Q0WUW8, Q9FFY9
      UniProtKB/TrEMBL
      A0A178UEI8, A0A5S9Y639
      Conserved Domains (1) summary
      cd11660
      Location:536 → 586
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

    2. NM_001343296.1 → NP_001330208.1  telomeric DNA binding protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81375, Q0WUW8, Q9FFY9
      UniProtKB/TrEMBL
      A0A178UEI8, A0A5S9Y639
      Conserved Domains (1) summary
      cd11660
      Location:536 → 586
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFY9.1

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