KAN Homeodomain-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KAN
Official Full Name: Homeodomain-like superfamily protein
Primary source: TAIR:AT5G16560
Locus tag: AT5G16560
See related: Araport:AT5G16560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: KAN1; KANADI; KANADI 1; MQK4.31; MQK4_31
Summary: Encodes a KANADI protein (KAN) that regulates organ polarity in Arabidopsis. KAN is required for abaxial identity in both leaves and carpels, and encodes a nuclear-localized protein in the GARP family of putative transcription factors. Together with KAN2, this gene appears to be involved in the development of the carpel and the outer integument of the ovule.Along with KAN2 and KAN4, KAN1 appears to be required for proper regulation of PIN1 in early embryogenesis.
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Genomic context

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See KAN in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (5406863..5411766, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factors KANADI 1, MYB DOMAIN PROTEIN 44, and PHYTOCHROME INTERACTING FACTOR 4 regulate long intergenic noncoding RNAs expressed in Arabidopsis roots.
Title: Transcription factors KANADI 1, MYB DOMAIN PROTEIN 44, and PHYTOCHROME INTERACTING FACTOR 4 regulate long intergenic noncoding RNAs expressed in Arabidopsis roots.
characterization of the cell type specific expression patterns of auxin responsive genes and identify a set of genes involved in organogenesis repressed by both REV and KAN1
Title: An integrated analysis of cell-type specific gene expression reveals genes regulated by REVOLUTA and KANADI1 in the Arabidopsis shoot apical meristem.
The authors show that leaf orientation, morphology and position are pre-patterned by HAT3 and KAN gene expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate plant development by localizing auxin response between their expression domains.
Title: Cell type boundaries organize plant development.
KAN1 acts upstream of several genes encoding auxin biosynthetic enzymes.KAN1 plays a role in shade-avoidance responses.KAN1 activity suppresses auxin synthesis and signaling.
Title: Meta-Analysis of Arabidopsis KANADI1 Direct Target Genes Identifies a Basic Growth-Promoting Module Acting Upstream of Hormonal Signaling Pathways.
ULT1 and KAN1 acting antagonistically to pattern the adaxial-abaxial polarity axis but jointly to pattern the apical-basal axis.
Title: ULTRAPETALA trxG genes interact with KANADI transcription factor genes to regulate Arabidopsis gynoecium patterning.
HD-ZIPIII and KANADI regulate tissue-specific transcription factors involved in subsidiary developmental decisions, nearly all major hormone pathways, and new actors (such as indeterminate domain4) in the ad/abaxial regulatory network.
Title: Establishing a framework for the Ad/abaxial regulatory network of Arabidopsis: ascertaining targets of class III homeodomain leucine zipper and KANADI regulation.
HD-ZIPIII and KANADI transcription factors pattern auxin accumulation and responsiveness in the embryo.
Title: Arabidopsis KANADI1 acts as a transcriptional repressor by interacting with a specific cis-element and regulates auxin biosynthesis, transport, and signaling in opposition to HD-ZIPIII factors.
a set of potential direct target genes of KAN1, were identified.
Title: Genome-wide identification of KANADI1 target genes.
Leaf polarity is established by the opposed actions of HD-ZIPIII and KANADI transcription factors.
Title: Genome-wide binding-site analysis of REVOLUTA reveals a link between leaf patterning and light-mediated growth responses.
Class III HD-ZIP and KANADI transcription factors control cambium activity: KANADI proteins by acting on auxin transport, and Class III HD-ZIP proteins by promoting axial cell elongation and xylem differentiation.
Title: Interplay of auxin, KANADI and Class III HD-ZIP transcription factors in vascular tissue formation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_121662.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abaxial cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaxial/abaxial axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carpel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant ovule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within polarity specification of adaxial/abaxial axis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xylem and phloem pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Homeodomain-like superfamily protein

NP_568334.1

KANADI (KAN); CONTAINS InterPro DOMAIN/s: Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), Myb-like DNA-binding domain, SHAQKYF class (InterPro:IPR006447), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: Homeodomain-like superfamily protein (TAIR:AT1G32240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

5406863..5411766 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121662.3 → NP_568334.1 Homeodomain-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568334.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93WJ9, Q94C09, Q9FFC8

UniProtKB/TrEMBL

A0A178UBS3, A0A5S9Y592

Conserved Domains (1) summary

TIGR01557
Location:220 → 273

myb_SHAQKYF; myb-like DNA-binding domain, SHAQKYF class