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    NUDT11 nudix hydrolase homolog 11 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834634, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUDT11
    Official Full Name
    nudix hydrolase homolog 11
    Primary source
    TAIR:AT5G45940
    Locus tag
    AT5G45940
    See related
    Araport:AT5G45940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana nudix hydrolase homolog 11; atnudt11; AtNUDT11; AtNUDX11; K15I22.14; K15I22_14; nudix hydrolase homolog 11; NUDX11
    Summary
    Encodes a CoA pyrophosphatase, also has ppGpp pyrophosphohydrolase and exhibits minor activity of NADH pyrophosphatase. Most strongly expressed in embryo cotyledon and hypocotyl, flower, and phloem of vascular tissue. Over-expression mutant had a bigger plant with wider rosette.
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    Genomic context

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    See NUDT11 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (18629562..18630706, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene SGNH hydrolase-type esterase superfamily protein Neighboring gene magnesium chelatase i2 Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and physiological characterization of Arabidopsis thaliana AtCoAse: a Nudix CoA hydrolyzing protein that improves plant development. Kupke T, et al. Physiol Plant, 2009 Apr. PMID 19340986
    2. A comparative analysis of the molecular characteristics of the Arabidopsis CoA pyrophosphohydrolases AtNUDX11, 15, and 15a. Ito D, et al. Biosci Biotechnol Biochem, 2012. PMID 22232253
    3. Enzymatic and molecular characterization of Arabidopsis ppGpp pyrophosphohydrolase, AtNUDX26. Ito D, et al. Biosci Biotechnol Biochem, 2012. PMID 23221701
    4. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. Ogawa T, et al. J Biol Chem, 2005 Jul 1. PMID 15878881
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. comparative studies of the gene regulation, the kinetic parameters, and the intracellular localization of AtNUDX11, 15, and 15a
      Title: A comparative analysis of the molecular characteristics of the Arabidopsis CoA pyrophosphohydrolases AtNUDX11, 15, and 15a.
    2. AtCoAse is a Nudix hydrolase. Transgenic Arabidopsis plants, with increased AtCoAse expression, show altered growth rates and development.
      Title: Biochemical and physiological characterization of Arabidopsis thaliana AtCoAse: a Nudix CoA hydrolyzing protein that improves plant development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001125908.1
    NM_001344651.1
    NM_123962.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coenzyme A diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables coenzyme A diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within malonyl-CoA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleoside phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nudix hydrolase homolog 11
    NP_001119380.1
    • nudix hydrolase homolog 11 (NUDT11); CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 15 (TAIR:AT1G28960.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_199406.1
    • nudix hydrolase homolog 11 (NUDT11); FUNCTIONS IN: hydrolase activity, NAD+ diphosphatase activity, CoA pyrophosphatase activity; INVOLVED IN: multicellular organismal development; LOCATED IN: cytosol; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 15 (TAIR:AT1G28960.5); Has 3666 Blast hits to 3665 proteins in 1325 species: Archae - 59; Bacteria - 2305; Metazoa - 169; Fungi - 188; Plants - 101; Viruses - 0; Other Eukaryotes - 844 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18629562..18630706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125908.1 → NP_001119380.1  nudix hydrolase homolog 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LET2
      Conserved Domains (1) summary
      cl00447
      Location:1 → 159
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. NM_123962.3 → NP_199406.1  nudix hydrolase homolog 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H699, Q8LET2, Q9FJ42
      UniProtKB/TrEMBL
      A0A5S9YBD6
      Conserved Domains (1) summary
      PLN02709
      Location:1 → 222
      PLN02709; nudix hydrolase

    3. NM_001344651.1 → NP_001331230.1  nudix hydrolase homolog 11 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDC5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LET2.2

    Gene LinkOut

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