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    DEG15 protease-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839726, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DEG15
    Official Full Name
    protease-like protein
    Primary source
    TAIR:AT1G28320
    Locus tag
    AT1G28320
    See related
    Araport:AT1G28320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtDEG15; degradation of periplasmic proteins 15; F3H9.3; F3H9_3
    Summary
    Mutants in this gene are defective in the processing of pre-glyoxysomal malate dehydrogenase (pre-gMDH) to gMDH.
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    Genomic context

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    See DEG15 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (9920219..9924488, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Plant self-incompatibility protein S1 family Neighboring gene Dof-type zinc finger DNA-binding family protein Neighboring gene pseudo Neighboring gene E3 ubiquitin-protein ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis. Schuhmann H, et al. Plant Physiol, 2008 Dec. PMID 18952862, Free PMC Article
    2. Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants. Helm M, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592111, Free PMC Article
    3. Calmodulin-like protein AtCML3 mediates dimerization of peroxisomal processing protease AtDEG15 and contributes to normal peroxisome metabolism. Dolze E, et al. Plant Mol Biol, 2013 Dec. PMID 23943091, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEG15 is a trypsin-like serine endopeptidase that mediates general processing of peroxisomal targeting signal 2 (PTS2)-containing proteins.
      Title: The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_102597.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protease-like protein
    NP_174153.2
    • DEG15; CONTAINS InterPro DOMAIN/s: Serine/cysteine peptidase, trypsin-like (InterPro:IPR009003); BEST Arabidopsis thaliana protein match is: DegP protease 1 (TAIR:AT3G27925.1); Has 3917 Blast hits to 3716 proteins in 1340 species: Archae - 34; Bacteria - 3021; Metazoa - 72; Fungi - 16; Plants - 139; Viruses - 0; Other Eukaryotes - 635 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9920219..9924488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102597.5 → NP_174153.2  protease-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174153.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZD4, Q9FZA5
      UniProtKB/TrEMBL
      A0A178WEL7, A0A5S9W964
      Conserved Domains (2) summary
      COG0265
      Location:471 → 622
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      pfam13365
      Location:376 → 594
      Trypsin_2; Trypsin-like peptidase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZD4.2

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