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    Myo6 myosin VI [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315840, updated on 27-Nov-2024

    Summary

    Official Symbol
    Myo6provided by RGD
    Official Full Name
    myosin VIprovided by RGD
    Primary source
    RGD:1560646
    See related
    EnsemblRapid:ENSRNOG00000011852 AllianceGenome:RGD:1560646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560646
    Summary
    Predicted to enable several functions, including ADP binding activity; actin filament binding activity; and calmodulin binding activity. Involved in response to xenobiotic stimulus. Located in several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Part of protein-containing complex. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 464.2), Lung (RPKM 161.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Myo6 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (89967351..90122219)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (81087157..81242022)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (87583649..87731271)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480213 Neighboring gene SUMO specific peptidase 6 Neighboring gene uncharacterized LOC134480212 Neighboring gene interphotoreceptor matrix proteoglycan 1 Neighboring gene 5-hydroxytryptamine receptor 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal motor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament-based movement ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear auditory receptor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cochlear hair cell ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic endocytic zone ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427259.1NP_001414188.1  unconventional myosin-VI

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZWC2
      Related
      ENSRNOP00000077341.1, ENSRNOT00000112254.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      89967351..90122219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766423.3XP_008764645.1  unconventional myosin-VI isoform X1

      See identical proteins and their annotated locations for XP_008764645.1

      UniProtKB/TrEMBL
      A0A8I5ZYN7, A0A8I6ACM8, A0A8I6AEW8
      Related
      ENSRNOP00000091730.1, ENSRNOT00000103299.2
      Conserved Domains (3) summary
      smart00242
      Location:52771
      MYSc; Myosin. Large ATPases
      cd01382
      Location:71759
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:11771267
      Myosin-VI_CBD; Myosin VI cargo binding domain
    2. XM_039082536.2XP_038938464.1  unconventional myosin-VI isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYN7, A0A8I6AEW8, D4A5I9
      Related
      ENSRNOP00000016428.7, ENSRNOT00000016428.10
    3. XM_008766425.4XP_008764647.1  unconventional myosin-VI isoform X3

      See identical proteins and their annotated locations for XP_008764647.1

      UniProtKB/TrEMBL
      A0A8I6AEW8
      Related
      ENSRNOP00000083134.2, ENSRNOT00000120263.2
      Conserved Domains (3) summary
      smart00242
      Location:52771
      MYSc; Myosin. Large ATPases
      cd01382
      Location:71759
      MYSc_Myo6; class VI myosin, motor domain
      pfam16521
      Location:11451235
      Myosin-VI_CBD; Myosin VI cargo binding domain
    4. XM_063265552.1XP_063121622.1  unconventional myosin-VI isoform X4

    5. XM_063265553.1XP_063121623.1  unconventional myosin-VI isoform X5

    RNA

    1. XR_005488326.2 RNA Sequence

    2. XR_005488327.2 RNA Sequence