Xpr1 xenotropic and polytropic retrovirus receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Xpr1provided by RGD
Full Name: xenotropic and polytropic retrovirus receptor 1provided by RGD
Primary source: RGD:1306554
See related: EnsemblRapid:ENSRNOG00000000042 AllianceGenome:RGD:1306554
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLC53A1
Summary: Predicted to enable several functions, including inositol hexakisphosphate binding activity; phosphate transmembrane transporter activity; and virus receptor activity. Predicted to be involved in cellular response to phosphate starvation; intracellular phosphate ion homeostasis; and phosphate ion transmembrane transport. Predicted to act upstream of or within response to virus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 119.5), Brain (RPKM 89.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (69991517..70136249, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (67441205..67585950, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (72918552..73056785, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BQ201960 (e-PCR)
- UniSTS:260894

AW531572 (e-PCR)
- UniSTS:245122

AW531572 (e-PCR)
- UniSTS:261842

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables inositol hexakisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 53 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105992.1 → NP_001099462.1 solute carrier family 53 member 1

See identical proteins and their annotated locations for NP_001099462.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

A0A8I6ABE7, A6ICY8

Related

ENSRNOP00000000049.6, ENSRNOT00000000049.8

Conserved Domains (2) summary

cd14477
Location:2 → 165

SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins

pfam03124
Location:268 → 617

EXS; EXS family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

69991517..70136249 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090615.2 → XP_038946543.1 solute carrier family 53 member 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JXZ7, A0A8I6GL93

Related

ENSRNOP00000070462.3, ENSRNOT00000081892.3

Conserved Domains (2) summary

cd14477
Location:2 → 143

SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins

pfam03124
Location:246 → 595

EXS; EXS family