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    Gng3 G protein subunit gamma 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114117, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gng3provided by RGD
    Official Full Name
    G protein subunit gamma 3provided by RGD
    Primary source
    RGD:620805
    See related
    EnsemblRapid:ENSRNOG00000019570 AllianceGenome:RGD:620805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg3d
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Predicted to be located in cell body; dendrite; and postsynaptic density. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in synapse. Orthologous to human GNG3 (G protein subunit gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 203.6), Testes (RPKM 95.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gng3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215160952..215162718, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205731837..205733603, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225033921..225035687, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene LRRN4 C-terminal like Neighboring gene UBX domain protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
    Names
    guanine nucleotide binding protein (G protein), gamma 3
    guanine nucleotide binding protein, gamma 3
    heterotrimeric guanine nucleotide-binding protein 3d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053658.1NP_446110.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

      See identical proteins and their annotated locations for NP_446110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HZV1, G3V8K2
      Related
      ENSRNOP00000026539.3, ENSRNOT00000026539.6
      Conserved Domains (1) summary
      smart00224
      Location:1375
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215160952..215162718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)