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    Fgf16 fibroblast growth factor 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60464, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fgf16provided by RGD
    Official Full Name
    fibroblast growth factor 16provided by RGD
    Primary source
    RGD:71052
    See related
    EnsemblRapid:ENSRNOG00000061530 AllianceGenome:RGD:71052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables fibroblast growth factor receptor binding activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of brown fat cell proliferation. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 151.6) and Adrenal (RPKM 8.7) See more
    Orthologs
    NEW
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    Genomic context

    See Fgf16 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (74882863..74893598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (70816658..70828028)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (76786728..76796311)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase 3, pseudogene 2 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 6 Neighboring gene transfer RNA glycine (anticodon ACC) 8 Neighboring gene U2 spliceosomal RNA Neighboring gene ATRX, chromatin remodeler Neighboring gene uncharacterized LOC134484000

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of brown fat cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT involved_in regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 16
    Names
    FGF-16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021867.4NP_068639.1  fibroblast growth factor 16

      See identical proteins and their annotated locations for NP_068639.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      O54769
      UniProtKB/TrEMBL
      A0A8I6AHM0, A6IV34
      Related
      ENSRNOP00000071308.1, ENSRNOT00000090665.3
      Conserved Domains (1) summary
      pfam00167
      Location:61187
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      74882863..74893598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100003.2XP_038955931.1  fibroblast growth factor 16 isoform X1

      Conserved Domains (1) summary
      cl00060
      Location:61126
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...