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    Psmc2 proteasome 26S subunit, ATPase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25581, updated on 27-Nov-2024

    Summary

    Official Symbol
    Psmc2provided by RGD
    Official Full Name
    proteasome 26S subunit, ATPase 2provided by RGD
    Primary source
    RGD:3428
    See related
    EnsemblRapid:ENSRNOG00000012026 AllianceGenome:RGD:3428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MSS1
    Summary
    Enables TBP-class protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in P-body and cytosol. Predicted to be part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 538.8), Muscle (RPKM 538.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psmc2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14148080..14162390, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13255850..13270160, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9867132..9881383, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene crystallin zeta like 1, pseudogene 1 Neighboring gene solute carrier family 26 member 5 Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene peptidase, mitochondrial processing subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables general transcription initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proteasome-activating activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables proteasome-activating activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome accessory complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    26S proteasome regulatory subunit 7
    Names
    26S protease regulatory subunit 7
    26S proteasome AAA-ATPase subunit RPT1
    proteasome (prosome, macropain) 26S subunit, ATPase 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033236.2NP_150239.2  26S proteasome regulatory subunit 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q62690, Q63347, Q6P7R9
      UniProtKB/TrEMBL
      A6K5A1, G3V7L6
      Related
      ENSRNOP00000016450.4, ENSRNOT00000016450.8
      Conserved Domains (1) summary
      COG1222
      Location:23430
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14148080..14162390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)