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    Gdi2 GDP dissociation inhibitor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29662, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gdi2provided by RGD
    Official Full Name
    GDP dissociation inhibitor 2provided by RGD
    Primary source
    RGD:61802
    See related
    EnsemblRapid:ENSRNOG00000018091 AllianceGenome:RGD:61802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gdi3
    Summary
    Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in vesicle-mediated transport. Is active in synapse. Orthologous to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1141.8), Spleen (RPKM 1135.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gdi2 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71559460..71586147, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66649616..66676299, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70299177..70325864, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 13 Neighboring gene uncharacterized LOC134482597 Neighboring gene transcription activation suppressor family member 2 Neighboring gene uncharacterized LOC120097798 Neighboring gene uncharacterized LOC120097902

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rab GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Rab GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Rab GDP-dissociation inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rab GDP dissociation inhibitor beta
    Names
    GDI-2
    GDI-3
    guanosine diphosphate (GDP) dissociation inhibitor 3
    guanosine diphosphate dissociation inhibitor 2
    guanosine diphosphate dissociation inhibitor 3
    rab GDI beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017276.2NP_058972.2  rab GDP dissociation inhibitor beta

      See identical proteins and their annotated locations for NP_058972.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061767
      UniProtKB/Swiss-Prot
      P50399, Q6P797
      UniProtKB/TrEMBL
      A0A8L2QEQ4, A6JLR2
      Related
      ENSRNOP00000024952.6, ENSRNOT00000024952.8
      Conserved Domains (1) summary
      pfam00996
      Location:1436
      GDI; GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71559460..71586147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)