Sctr secretin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sctrprovided by MGI
Official Full Name: secretin receptorprovided by MGI
Primary source: MGI:MGI:2441720
See related: Ensembl:ENSMUSG00000026387 AllianceGenome:MGI:2441720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6530402O03Rik
Summary: Enables secretin receptor activity. Involved in several processes, including diet induced thermogenesis; intracellular water homeostasis; and renal water absorption. Predicted to be located in cytoplasmic microtubule. Predicted to be active in plasma membrane. Orthologous to human SCTR (secretin receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 11.4), adrenal adult (RPKM 3.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.57 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (119934710..119991269)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (120006879..120063539)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
Title: Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice.
Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
Title: Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading.
Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
Title: Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.
Secretin receptor-deficient mice exhibit robust food anticipatory activity.
Title: Secretin receptor-deficient mice exhibit robust food anticipatory activity.
Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
Title: Secretin receptor-deficient mice exhibit altered circadian rhythm in wheel-running activity.
High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
The involvement of secretin (SCT) and its receptor (SCTR) in angiotensin II (ANGII)-mediated osmoregulation by forming SCTR/ angiotensin II type 1 receptor (AT1R) heteromer is well established. In this study, we demonstrated that SCTR/AT1R complex can mediate ANGII-induced aldosterone secretion/release through potentiating calcium mobilization.
Title: Role of SCTR/AT1aR heteromer in mediating ANGII-induced aldosterone secretion.
Enhanced senescence levels in cholangiocytes from Mdr2(-/-) mice were reversed to normal in SR(-/-)/Mdr2(-/-) mice.
Title: Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(-/-) mice by diminishing senescence of cholangiocytes.
Knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.
Title: Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

D1Mit54 (e-PCR), detects polymorphism
- UniSTS:128908

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables secretin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables secretin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables secretin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of appetite	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretin receptor

Names: SCT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012322.2 → NP_001012322.2 secretin receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001012322.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK032652, BC089355

Consensus CDS

CCDS48341.1

UniProtKB/TrEMBL

H7BX37

Related

ENSMUSP00000072660.5, ENSMUST00000072886.11

Conserved Domains (2) summary

cd15275
Location:153 → 419

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:77 → 140

HRM; Hormone receptor domain
NM_001311077.1 → NP_001298006.1 secretin receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001298006.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK032652, BC089355

Consensus CDS

CCDS78668.1

UniProtKB/Swiss-Prot

Q5FWI2, Q80T66

Related

ENSMUSP00000139932.2, ENSMUST00000189037.2

Conserved Domains (2) summary

pfam00002
Location:138 → 383

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:63 → 125

HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

119934710..119991269

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529684.5 → XP_006529747.1 secretin receptor isoform X1

Conserved Domains (2) summary

cd15275
Location:153 → 417

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:77 → 140

HRM; Hormone receptor domain
XM_006529686.5 → XP_006529749.1 secretin receptor isoform X2

Conserved Domains (2) summary

cd15275
Location:138 → 404

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:63 → 125

HRM; Hormone receptor domain
XM_036165671.1 → XP_036021564.1 secretin receptor isoform X6

Conserved Domains (3) summary

pfam02793
Location:77 → 140

HRM; Hormone receptor domain

cd14964
Location:155 → 180

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:153 → 352

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036165670.1 → XP_036021563.1 secretin receptor isoform X6

Conserved Domains (3) summary

pfam02793
Location:77 → 140

HRM; Hormone receptor domain

cd14964
Location:155 → 180

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:153 → 352

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036165668.1 → XP_036021561.1 secretin receptor isoform X3

Conserved Domains (2) summary

cd15275
Location:153 → 408

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:77 → 140

HRM; Hormone receptor domain
XM_011248029.2 → XP_011246331.1 secretin receptor isoform X4

See identical proteins and their annotated locations for XP_011246331.1

Conserved Domains (2) summary

cd15275
Location:67 → 333

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:2 → 54

HRM; Hormone receptor domain
XM_036165669.1 → XP_036021562.1 secretin receptor isoform X4

Conserved Domains (2) summary

cd15275
Location:67 → 333

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:2 → 54

HRM; Hormone receptor domain
XM_006529688.4 → XP_006529751.1 secretin receptor isoform X4

See identical proteins and their annotated locations for XP_006529751.1

Conserved Domains (2) summary

cd15275
Location:67 → 333

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:2 → 54

HRM; Hormone receptor domain
XM_011248031.4 → XP_011246333.1 secretin receptor isoform X5

Conserved Domains (2) summary

cd15275
Location:62 → 328

7tmB1_secretin; secretin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

cl02422
Location:22 → 49

HRM; Hormone receptor domain
XM_030254873.2 → XP_030110733.1 secretin receptor isoform X8

Conserved Domains (2) summary

cd14964
Location:53 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:46 → 281

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006529689.4 → XP_006529752.1 secretin receptor isoform X7

Conserved Domains (2) summary

cd14964
Location:53 → 75

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:46 → 283

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006529690.3 → XP_006529753.1 secretin receptor isoform X9

Conserved Domains (2) summary

cd14964
Location:1 → 25

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:1 → 187

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily