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    WRKY12 WRKY family transcription factor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819083, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WRKY12
    Official Full Name
    WRKY family transcription factor
    Primary source
    TAIR:AT2G44745
    Locus tag
    AT2G44745
    See related
    Araport:AT2G44745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtWRKY12; WRKY DNA-binding protein 12
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    Genomic context

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    See WRKY12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (18447203..18449093, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cyclin p4;1 Neighboring gene miscRNA Neighboring gene thiamine pyrophosphokinase 2 Neighboring gene dihydroorotate dehydrogenase (DUF3598) Neighboring gene ELMO/CED-12 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcription factor WRKY12 negatively regulates iron entry into seeds in Arabidopsis. Wu X, et al. J Exp Bot, 2023 Jan 1. PMID 36223275
    2. Mutation of WRKY transcription factors initiates pith secondary wall formation and increases stem biomass in dicotyledonous plants. Wang H, et al. Proc Natl Acad Sci U S A, 2010 Dec 21. PMID 21135241, Free PMC Article
    3. WRKY33 interacts with WRKY12 protein to up-regulate RAP2.2 during submergence induced hypoxia response in Arabidopsis thaliana. Tang H, et al. New Phytol, 2021 Jan. PMID 33098101
    4. WRKY12 represses GSH1 expression to negatively regulate cadmium tolerance in Arabidopsis. Han Y, et al. Plant Mol Biol, 2019 Jan. PMID 30617455
    5. Arabidopsis WRKY Transcription Factors WRKY12 and WRKY13 Oppositely Regulate Flowering under Short-Day Conditions. Li W, et al. Mol Plant, 2016 Nov 7. PMID 27592586

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WRKY33 interacts with WRKY12 protein to up-regulate RAP2.2 during submergence induced hypoxia response in Arabidopsis thaliana.
      Title: WRKY33 interacts with WRKY12 protein to up-regulate RAP2.2 during submergence induced hypoxia response in Arabidopsis thaliana.
    2. WRKY transcription factors WRKY12 and WRKY13 interact with SPL10 to modulate age-mediated flowering.
      Title: WRKY transcription factors WRKY12 and WRKY13 interact with SPL10 to modulate age-mediated flowering.
    3. The results suggest that WRKY12 directly targets GSH1 and indirectly represses phytochelatin (PC) synthesis-related gene expression to negatively regulate Cd accumulation and tolerance in Arabidopsis.
      Title: WRKY12 represses GSH1 expression to negatively regulate cadmium tolerance in Arabidopsis.
    4. WRKY12 and WRKY13 oppositely modulate flowering time under SD conditions
      Title: Arabidopsis WRKY Transcription Factors WRKY12 and WRKY13 Oppositely Regulate Flowering under Short-Day Conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_130039.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    WRKY family transcription factor
    NP_566025.2
    • WRKY family transcription factor; CONTAINS InterPro DOMAIN/s: DNA-binding WRKY (InterPro:IPR003657); BEST Arabidopsis thaliana protein match is: WRKY DNA-binding protein 13 (TAIR:AT4G39410.1); Has 3506 Blast hits to 3049 proteins in 189 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 3483; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18447203..18449093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130039.3 → NP_566025.2  WRKY family transcription factor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566025.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S8S5, Q93WY4
      UniProtKB/TrEMBL
      A0A654FCI2, A0MET5, Q1PEU5
      Conserved Domains (1) summary
      smart00774
      Location:144 → 201
      WRKY; DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93WY4.1

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