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    HEXO3 beta-hexosaminidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842871, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEXO3
    Official Full Name
    beta-hexosaminidase 3
    Primary source
    TAIR:AT1G65590
    Locus tag
    AT1G65590
    See related
    Araport:AT1G65590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHEX1; beta-hexosaminidase 3; F5I14.12; F5I14_12
    Summary
    Encodes a protein with beta-hexosaminidase activity. Located on the plasma membrane.
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    Genomic context

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    See HEXO3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (24385552..24391208)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Endonuclease/exonuclease/phosphatase family protein Neighboring gene miscRNA Neighboring gene Six-hairpin glycosidases superfamily protein Neighboring gene Lateral organ boundaries (LOB) domain family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana. Liebminger E, et al. J Biol Chem, 2011 Mar 25. PMID 21252225, Free PMC Article
    2. Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases. Strasser R, et al. Plant Physiol, 2007 Sep. PMID 17644627, Free PMC Article
    3. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
    4. Cell wall proteins in apoplastic fluids of Arabidopsis thaliana rosettes: identification by mass spectrometry and bioinformatics. Boudart G, et al. Proteomics, 2005 Jan. PMID 15593128
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana.
      Title: Beta-N-acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana.
    2. capable of removing terminal GlcNAc residues from the alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference
      Title: Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases.
    Submit: New GeneRIF Correction

    General gene information

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    NM_105233.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-hexosaminidase 3
    NP_176737.2
    • beta-hexosaminidase 3 (HEXO3); FUNCTIONS IN: hexosaminidase activity, beta-N-acetylhexosaminidase activity; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: cell wall, plasma membrane, plant-type cell wall; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 20, catalytic core (InterPro:IPR015883), Beta-N-acetylhexosaminidase, subunit a/b (InterPro:IPR015882), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, family 20 (InterPro:IPR001540), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: beta-hexosaminidase 1 (TAIR:AT3G55260.1); Has 3849 Blast hits to 3760 proteins in 723 species: Archae - 6; Bacteria - 2490; Metazoa - 475; Fungi - 225; Plants - 125; Viruses - 0; Other Eukaryotes - 528 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24385552..24391208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105233.5 → NP_176737.2  beta-hexosaminidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176737.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04477, Q8L7S6
      UniProtKB/TrEMBL
      A0A178W0N8, A0A654EL99
      Conserved Domains (2) summary
      cd06562
      Location:182 → 512
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:34 → 157
      Glycohydro_20b2; beta-acetyl hexosaminidase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L7S6.1

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