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    BIP3 Heat shock protein 70 (Hsp 70) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837429, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIP3
    Official Full Name
    Heat shock protein 70 (Hsp 70) family protein
    Primary source
    TAIR:AT1G09080
    Locus tag
    AT1G09080
    See related
    Araport:AT1G09080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    binding protein 3; F7G19.5; F7G19_5
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    Genomic context

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    See BIP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (2929217..2931850, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene arginine-glutamic acid dipeptide repeat protein Neighboring gene JmjC domain protein JMJ24 Neighboring gene soybean gene regulated by cold-2 Neighboring gene respiratory burst oxidase-like protein Neighboring gene 26S proteasome AAA-ATPase subunit RPT5B Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum-mediated unfolded protein response is an integral part of singlet oxygen signalling in plants. Beaugelin I, et al. Plant J, 2020 Jun. PMID 31975462
    2. The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. Mathur S, et al. Plant Physiol, 2011 Dec. PMID 22021418, Free PMC Article
    3. Constitutive BiP protein accumulation in Arabidopsis mutants defective in a gene encoding chloroplast-resident stearoyl-acyl carrier protein desaturase. Iwata Y, et al. Genes Cells, 2018 Jun. PMID 29688606
    4. BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana. Maruyama D, et al. Plant Signal Behav, 2015. PMID 26251880, Free PMC Article
    5. The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis. Ma ZX, et al. PLoS One, 2015. PMID 26186593, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified a mutant that shows constitutive BiP3 protein accumulation without treatment with endoplasmic reticulum (ER) stress inducers. The causal gene for constitutive BiP3 accumulation was found to be SSI2 gene; finding suggests a genetic link between fatty acid metabolism in the chloroplast and ER functions.
      Title: Constitutive BiP protein accumulation in Arabidopsis mutants defective in a gene encoding chloroplast-resident stearoyl-acyl carrier protein desaturase.
    2. BIP3 supports the early stages of female gametophyte development, but not polar nuclear fusion, in the absence of BiP1 and BiP2.
      Title: BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana.
    3. the DnaJ domain of TMS1 could interact with BiP1 and BiP3, and could stimulate their ATPase enzyme activities.
      Title: The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis.
    4. Results show that bZIP17 regulate the accumulation of the transcript for the chaperone BiP3 under salt stress conditions.
      Title: bZIP17 and bZIP60 Regulate the Expression of BiP3 and Other Salt Stress Responsive Genes in an UPR-Independent Manner in Arabidopsis thaliana.
    5. the bip1 bip2 bip3 triple mutation is lethal in pollen.
      Title: Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
    6. Data show detectable amounts of YFP-bZIP28 escaped from endoplasmic reticulum (ER) to nuclei under unstressed conditions in the bip1/bip1 bip2/+ and in the bip1/+ bip2/bip2 and bip3 mutant lines.
      Title: BINDING PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100779.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube growth IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to singlet oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    Heat shock protein 70 (Hsp 70) family protein
    NP_001184944.1
    • BIP3; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to heat, pollen tube growth; LOCATED IN: endoplasmic reticulum lumen; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: Heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G42020.1).
    NP_172382.4
    • BIP3; FUNCTIONS IN: ATP binding; INVOLVED IN: protein folding, response to heat, pollen tube growth; LOCATED IN: endoplasmic reticulum lumen; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock protein 70 (Hsp 70) family protein (TAIR:AT5G28540.1); Has 36561 Blast hits to 35981 proteins in 4871 species: Archae - 169; Bacteria - 17528; Metazoa - 4151; Fungi - 1824; Plants - 1283; Viruses - 337; Other Eukaryotes - 11269 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2929217..2931850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198015.2 → NP_001184944.1  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WHW4, A0A5S9TDP6
      Conserved Domains (1) summary
      PTZ00009
      Location:43 → 648
      PTZ00009; heat shock 70 kDa protein; Provisional

    2. NM_100779.5 → NP_172382.4  Heat shock protein 70 (Hsp 70) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172382.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HZD5, O04022, Q8H1B3
      Conserved Domains (2) summary
      cd10241
      Location:50 → 423
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      PTZ00009
      Location:53 → 658
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1B3.1

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