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    MMZ1 MMS ZWEI homologue 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838935, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MMZ1
    Official Full Name
    MMS ZWEI homologue 1
    Primary source
    TAIR:AT1G23260
    Locus tag
    AT1G23260
    See related
    Araport:AT1G23260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F26F24.10; F26F24_10; MMS ZWEI homologue 1; UBIQUITIN E2 VARIANT 1A; UEV1A
    Summary
    MMZ1/UEV1A encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1A can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. However, a combination of MMZ1/UEV1A and UBC13A do not do a good job of rescuing an mms2 ubc13 double mutant in yeast. MMZ1/UEV1A transcripts are found at low levels in most plant organs, but cannot be detected in the pollen. Transcript levels do not appear to be stress-inducible. The uev1a-1 mutant shows normal sensitivity to MMS in germination assays suggesting that UEV1A is not required for DNA damage tolerance during this developmental stage.
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    Genomic context

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    See MMZ1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (8256854..8258725, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Caleosin-related family protein Neighboring gene Caleosin-related family protein Neighboring gene uncharacterized protein Neighboring gene MAK16 protein-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal extension of Arabidopsis Uev1A/B with putative prenylation site plays critical roles in protein interaction, subcellular distribution and membrane association. Wang Q, et al. Plant Sci, 2020 Feb. PMID 31928655
    2. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332597.1
    NM_102175.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MMS ZWEI homologue 1
    NP_564191.1
    • MMS ZWEI homologue 1 (MMZ1); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: MMS ZWEI homologue 2 (TAIR:AT1G70660.1); Has 4438 Blast hits to 4438 proteins in 315 species: Archae - 0; Bacteria - 0; Metazoa - 2178; Fungi - 730; Plants - 896; Viruses - 0; Other Eukaryotes - 634 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8256854..8258725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102175.4 → NP_564191.1  MMS ZWEI homologue 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YP0, Q9LR36
      UniProtKB/TrEMBL
      A0A178WAQ1, A0A5S9VM85
      Conserved Domains (1) summary
      smart00212
      Location:15 → 150
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001332597.1 → NP_001320610.1  MMS ZWEI homologue 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W8R0, A0A1P8AND1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93YP0.1

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