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    TMM Leucine-rich repeat (LRR) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844348, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TMM
    Official Full Name
    Leucine-rich repeat (LRR) family protein
    Primary source
    TAIR:AT1G80080
    Locus tag
    AT1G80080
    See related
    Araport:AT1G80080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtRLP17; F18B13.16; F18B13_16; Receptor Like Protein 17; TOO MANY MOUTHS
    Summary
    Encodes a transmembrane leucine-repeat containing receptor-like protein that is expressed in proliferative postprotodermal cells. Recessive mutation leads to disruption of asymmetric cell division during stomata development. Its transcript levels change after inducing MUTE expression in a mute background.
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    Genomic context

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    See TMM in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (30127819..30129649, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like superfamily protein Neighboring gene Pre-mRNA-processing-splicing factor Neighboring gene Cystathionine beta-synthase (CBS) family protein Neighboring gene histidine phosphotransfer protein 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ERECTA and BAK1 Receptor Like Kinases Interact to Regulate Immune Responses in Arabidopsis. Jordá L, et al. Front Plant Sci, 2016. PMID 27446127, Free PMC Article
    2. Oriented asymmetric divisions that generate the stomatal spacing pattern in arabidopsis are disrupted by the too many mouths mutation. Geisler M, et al. Plant Cell, 2000 Nov. PMID 11090210, Free PMC Article
    3. TOO MANY MOUTHS promotes cell fate progression in stomatal development of Arabidopsis stems. Bhave NS, et al. Planta, 2009 Jan. PMID 18979118
    4. New phenotypic characteristics of three tmm alleles in Arabidopsis thaliana. Yan L, et al. Plant Cell Rep, 2014 May. PMID 24553751
    5. Organ-specific effects of brassinosteroids on stomatal production coordinate with the action of Too Many Mouths. Wang M, et al. J Integr Plant Biol, 2015 Mar. PMID 25234048

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that TMM dictates the specificity of ERECTA family for the perception of different epidermal patterning factor peptides (EPfs), thus functioning as a specificity switch for the regulation of the activities of ERfs.
      Title: A receptor-like protein acts as a specificity switch for the regulation of stomatal development.
    2. The tmm-1 mutation is epistatic to the atgpi8-1 mutation, indicating that either TMM is a GPI-AP or there is another GPI-AP regulating stomata development whose function is dependent upon TMM.
      Title: A Mutation in the Catalytic Subunit of the Glycosylphosphatidylinositol Transamidase Disrupts Growth, Fertility, and Stomata Formation.
    3. Brassinosteroid organ-specific effects on stomatal production might coordinate with the TMM organ-specific actions.
      Title: Organ-specific effects of brassinosteroids on stomatal production coordinate with the action of Too Many Mouths.
    4. TMM was involved in Abscisic Acid (ABA) signaling transduction. Overexpression of TMM resulted in the reduction of leaf trichomes and their branches.
      Title: New phenotypic characteristics of three tmm alleles in Arabidopsis thaliana.
    5. CHAL and the EPFs both act through ER family receptors to repress stomatal production, but are subject to opposite regulation by TMM
      Title: Regional specification of stomatal production by the putative ligand CHALLAH.
    6. TMM interacts with other proteins to modulate precursor cell fate and progression in an organ and domain-specific manner.
      Title: TOO MANY MOUTHS promotes cell fate progression in stomatal development of Arabidopsis stems.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106657.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to abscisic acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in stomatal complex formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat (LRR) family protein
    NP_178125.1
    • TOO MANY MOUTHS (TMM); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat (InterPro:IPR001611); BEST Arabidopsis thaliana protein match is: receptor like protein 29 (TAIR:AT2G42800.1); Has 88991 Blast hits to 28047 proteins in 1079 species: Archae - 16; Bacteria - 3330; Metazoa - 23111; Fungi - 805; Plants - 56845; Viruses - 0; Other Eukaryotes - 4884 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30127819..30129649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106657.3 → NP_178125.1  Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178125.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWY1, Q9SSD1
      UniProtKB/TrEMBL
      A0A178WJY8, A0A5S9WW10
      Conserved Domains (2) summary
      PLN00113
      Location:150 → 392
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:161 → 184
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SSD1.1

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