CCS copper chaperone for SOD1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CCS
Official Full Name: copper chaperone for SOD1
Primary source: TAIR:AT1G12520
Locus tag: AT1G12520
See related: Araport:AT1G12520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCCS; copper chaperone for SOD1; COPPER/ZINC SUPEROXIDE DISMUTASE COPPER CHAPERONE; F5O11.26; F5O11_26
Summary: Copper-zinc superoxide dismutase copper chaperone (delivers copper to the Cu-Zn superoxide dismutase). Localized to the chloroplast. Expressed in roots and shoots. Up-regulated in response to copper and senescence. The AtACC activates all three CuZnSOD activities located in three different subcellular compartments. Contains three domains, central, ATX-1 like and C-terminal. ATX-1 like domain essential for the copper chaperone function of AtCCS in planta.
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Genomic context

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See CCS in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (4267074..4268982, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that transgenic plants expressing miR398-resistant forms of CSD1, CSD2 and CCS under the control of their native promoters are more sensitive to heat stress.
Title: Heat stress induction of miR398 triggers a regulatory loop that is critical for thermotolerance in Arabidopsis.
miR398 links expression of the three major chloroplast copper proteins, plastocyanin, CCS1 and Csd2, to copper availability.
Title: The strength of the miR398-Csd2-CCS1 regulon is subject to natural variation in Arabidopsis thaliana.
CCS1 gene encodes both a cytosolic and a chloroplastic form of CCS1. miR398 directs the post-transcriptional regulation of CCS1 mRNAs by cleavage and AGO10-mediated translational repression. [CCS1]
Title: microRNA-directed cleavage and translational repression of the copper chaperone for superoxide dismutase mRNA in Arabidopsis.
The structure and function of the CCS gene of A. thaliana, including its copper and protein binding domains, are reported.
Title: A copper chaperone for superoxide dismutase that confers three types of copper/zinc superoxide dismutase activity in Arabidopsis.
Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD [AtCCS]
Title: AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001035952.3

Supported by ESTs:

NM_001035953.2

Supported by ESTs:

NM_101123.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase copper chaperone activity	IGI Inferred from Genetic Interaction more info	PubMed
enables superoxide dismutase copper chaperone activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular copper ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: copper chaperone for SOD1

NP_001031029.1

copper chaperone for SOD1 (CCS); FUNCTIONS IN: superoxide dismutase copper chaperone activity, superoxide dismutase activity; INVOLVED IN: cellular copper ion homeostasis; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), Superoxide dismutase, copper/zinc binding (InterPro:IPR001424); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 2 (TAIR:AT2G28190.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001031030.1

copper chaperone for SOD1 (CCS); FUNCTIONS IN: superoxide dismutase copper chaperone activity, superoxide dismutase activity; INVOLVED IN: cellular copper ion homeostasis; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Superoxide dismutase, copper/zinc binding (InterPro:IPR001424); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 2 (TAIR:AT2G28190.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_563910.2

copper chaperone for SOD1 (CCS); FUNCTIONS IN: superoxide dismutase copper chaperone activity, superoxide dismutase activity; INVOLVED IN: cellular copper ion homeostasis; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Superoxide dismutase, copper/zinc binding (InterPro:IPR001424), Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: copper/zinc superoxide dismutase 2 (TAIR:AT2G28190.1); Has 3500 Blast hits to 3494 proteins in 885 species: Archae - 2; Bacteria - 672; Metazoa - 1229; Fungi - 394; Plants - 875; Viruses - 122; Other Eukaryotes - 206 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4267074..4268982 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101123.4 → NP_563910.2 copper chaperone for SOD1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563910.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4ZJI5, Q67Y08, Q681F4, Q94A55, Q9LD47, Q9SPD6

UniProtKB/TrEMBL

A0A178WIN2, A0A5S9U2G6, A0A654E995

Conserved Domains (1) summary

PLN02957
Location:82 → 320

PLN02957; copper, zinc superoxide dismutase
NM_001035952.3 → NP_001031029.1 copper chaperone for SOD1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031029.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WK61

Conserved Domains (3) summary

PLN02957
Location:1 → 229

PLN02957; copper, zinc superoxide dismutase

cd00371
Location:4 → 58

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

pfam00080
Location:81 → 188

Sod_Cu; Copper/zinc superoxide dismutase (SODC)
NM_001035953.2 → NP_001031030.1 copper chaperone for SOD1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031030.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WK61

Conserved Domains (2) summary

PLN02957
Location:1 → 184

PLN02957; copper, zinc superoxide dismutase

pfam00080
Location:36 → 143

Sod_Cu; Copper/zinc superoxide dismutase (SODC)