U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MC2 metacaspase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828614, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MC2
    Official Full Name
    metacaspase 2
    Primary source
    TAIR:AT4G25110
    Locus tag
    AT4G25110
    See related
    Araport:AT4G25110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMC2; AtMCP1c; F24A6.7; MCP1c; metacaspase 1c; metacaspase 2
    Summary
    Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MC2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (12887474..12890262, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene magnesium-protoporphyrin IX methyltransferase Neighboring gene Riboflavin synthase-like superfamily protein Neighboring gene Fe superoxide dismutase 1 Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene peptide met sulfoxide reductase 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The prodomain of Arabidopsis metacaspase 2 positively regulates immune signaling mediated by pattern-recognition receptors. Wu D, et al. New Phytol, 2024 Jan. PMID 37920109
    2. Arabidopsis type I metacaspases control cell death. Coll NS, et al. Science, 2010 Dec 3. PMID 21097903
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    NM_001036634.1
    NM_118643.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    metacaspase 2
    NP_001031711.1
    • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735), Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194241.3
    • metacaspase 2 (MC2); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600), Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: metacaspase 1 (TAIR:AT1G02170.1); Has 7673 Blast hits to 3913 proteins in 538 species: Archae - 9; Bacteria - 793; Metazoa - 961; Fungi - 920; Plants - 3202; Viruses - 585; Other Eukaryotes - 1203 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12887474..12890262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118643.5 → NP_194241.3  metacaspase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194241.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682S4, Q7XJE5, Q9SW15
      UniProtKB/TrEMBL
      A0A178V2G1, A0A5S9XVM7
      Conserved Domains (2) summary
      TIGR01053
      Location:4 → 34
      LSD1; zinc finger domain, LSD1 subclass
      pfam00656
      Location:116 → 352
      Peptidase_C14; Caspase domain

    2. NM_001036634.1 → NP_001031711.1  metacaspase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7XJE5
      Conserved Domains (2) summary
      TIGR01053
      Location:4 → 34
      LSD1; zinc finger domain, LSD1 subclass
      pfam00656
      Location:116 → 349
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XJE5.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.