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    EIF3C eukaryotic translation initiation factor 3C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824781, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIF3C
    Official Full Name
    eukaryotic translation initiation factor 3C
    Primary source
    TAIR:AT3G56150
    Locus tag
    AT3G56150
    See related
    Araport:AT3G56150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEIF3C-1; ATTIF3C1; EIF3C-1; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 8; eukaryotic translation initiation factor 3C; TIF3C1
    Summary
    member of eIF3c - eukaryotic initiation factor 3c
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    Genomic context

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    See EIF3C in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20833410..20837275, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene biotin/lipoyl attachment domain-containing protein Neighboring gene DUF399 family protein, putative (DUF399 and DUF3411) Neighboring gene Sodium Bile acid symporter family Neighboring gene Ca-2+ dependent nuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Viral factor TAV recruits TOR/S6K1 signalling to activate reinitiation after long ORF translation. Schepetilnikov M, et al. EMBO J, 2011 Apr 6. PMID 21343906, Free PMC Article
    2. The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. Karniol B, et al. FEBS Lett, 1998 Nov 13. PMID 9849901
    3. TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h. Schepetilnikov M, et al. EMBO J, 2013 Apr 17. PMID 23524850, Free PMC Article
    4. A new plant protein interacts with eIF3 and 60S to enhance virus-activated translation re-initiation. Thiébeauld O, et al. EMBO J, 2009 Oct 21. PMID 19745810, Free PMC Article
    5. Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. Yahalom A, et al. J Biol Chem, 2001 Jan 5. PMID 11029466

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203173.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3C
    NP_001190102.1
    • eukaryotic translation initiation factor 3C (EIF3C); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Proteasome component (PCI) domain (InterPro:IPR000717), Eukaryotic translation initiation factor 3 subunit 8, N-terminal (InterPro:IPR008905); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 3 subunit C2 (TAIR:AT3G22860.1).
    NP_191174.1
    • eukaryotic translation initiation factor 3C (EIF3C); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: translational initiation; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Proteasome component (PCI) domain (InterPro:IPR000717), Eukaryotic translation initiation factor 3 subunit 8, N-terminal (InterPro:IPR008905); BEST Arabidopsis thaliana protein match is: eukaryotic translation initiation factor 3 subunit C2 (TAIR:AT3G22860.1); Has 10199 Blast hits to 6703 proteins in 565 species: Archae - 12; Bacteria - 1147; Metazoa - 3521; Fungi - 1145; Plants - 1081; Viruses - 87; Other Eukaryotes - 3206 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20833410..20837275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115473.3 → NP_191174.1  eukaryotic translation initiation factor 3C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49160, Q9LYM6
      UniProtKB/TrEMBL
      A0A5S9XLG4, A0A654FH19
      Conserved Domains (3) summary
      smart00753
      Location:705 → 793
      PAM; PCI/PINT associated module
      pfam05470
      Location:34 → 636
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
      pfam12226
      Location:12 → 51
      Astro_capsid_p; Turkey astrovirus capsid protein

    2. NM_001203173.1 → NP_001190102.1  eukaryotic translation initiation factor 3C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49160, Q9LYM6
      UniProtKB/TrEMBL
      A0A5S9XLG4, A0A654FH19
      Conserved Domains (3) summary
      smart00753
      Location:705 → 793
      PAM; PCI/PINT associated module
      pfam05470
      Location:34 → 636
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
      pfam12226
      Location:12 → 51
      Astro_capsid_p; Turkey astrovirus capsid protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49160.2

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