GUN5 magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GUN5
Official Full Name: magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH)
Primary source: TAIR:AT5G13630
Locus tag: AT5G13630
See related: Araport:AT5G13630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ABA-BINDING PROTEIN; ABAR; CCH; CCH1; CHLH; CONDITIONAL CHLORINA; GENOMES UNCOUPLED 5; H SUBUNIT OF MG-CHELATASE; T6I14.12
Summary: Encodes magnesium chelatase involved in plastid-to-nucleus signal transduction.
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Genomic context

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See GUN5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 5

Sequence:: Chromosome: 5; NC_003076.8 (4387307..4392429, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Thylakoid Membrane Protein Functions Synergistically with GUN5 in Chlorophyll Biosynthesis.
Title: A Thylakoid Membrane Protein Functions Synergistically with GUN5 in Chlorophyll Biosynthesis.
Identification of small non-coding RNAs responsive to GUN1 and GUN5 related retrograde signals in Arabidopsis thaliana.
Title: Identification of small non-coding RNAs responsive to GUN1 and GUN5 related retrograde signals in Arabidopsis thaliana.
Results suggest that the genomes uncoupled 1 (GUN1) and genomes uncoupled 5 (GUN5)-involved plastid-to-nucleus retrograde communication played a role in regulating acetyl-CoA carboxylase 2 (ACC2).
Title: A role of GUNs-Involved retrograde signaling in regulating Acetyl-CoA carboxylase 2 in Arabidopsis.
Findings reveal an auto-adaptation loop pathway that plant cells optimize particular needs of chloroplasts in stabilizing photosynthetic complexes by relaying the GUN5-dependent plastid signal(s) to activate the heat-responsive expression of HSP21 in the nucleus during adaptation to heat stress in plants.
Title: Identification of core subunits of photosystem II as action sites of HSP21, which is activated by the GUN5-mediated retrograde pathway in Arabidopsis.
Gun5 role in chloroplast development and tetrapyrrole biosynthesis
Title: Modulation of biosynthesis of photosynthetic pigments and light-harvesting complex in wild-type and gun5 mutant of Arabidopsis thaliana during impaired chloroplast development.
OST1 functions downstream of ABAR in abscisic acid receptor signalling in guard cells. Consistent with this, ABAR protein is phosphorylated, but independently of the OST1 protein kinase.
Title: A link between magnesium-chelatase H subunit and sucrose nonfermenting 1 (SNF1)-related protein kinase SnRK2.6/OST1 in Arabidopsis guard cell signalling in response to abscisic acid.
findings provide clear evidence that the Mg-chelatase-catalyzed Mg-ProtoIX production is distinct from ABA signaling, giving information to understand the mechanism by which the two cellular processes differs at the molecular level
Title: Roles of the different components of magnesium chelatase in abscisic acid signal transduction.
HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expression of photosynthesis-associated nuclear genes
Title: Interplay between Heat Shock Protein 90 and HY5 controls PhANG expression in response to the GUN5 plastid signal.
A missense mutation of CHLH (L690 to F) is responsible for phenotype in which stomatal movements are insensitive to abscisic acid.
Title: Mg-chelatase H subunit affects ABA signaling in stomatal guard cells, but is not an ABA receptor in Arabidopsis thaliana.
ChlH and GUN4 use distinct mechanisms to associate with chloroplast membranes.
Title: GUN4-porphyrin complexes bind the ChlH/GUN5 subunit of Mg-Chelatase and promote chlorophyll biosynthesis in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001085109.1

Supported by ESTs:

NM_121366.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium chelatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium chelatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chlorophyll biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast inner membrane	NAS Non-traceable Author Statement more info	PubMed
part_of magnesium chelatase complex	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH)

NP_001078578.1

GENOMES UNCOUPLED 5 (GUN5); FUNCTIONS IN: magnesium chelatase activity; INVOLVED IN: chlorophyll biosynthetic process, biosynthetic process; LOCATED IN: mitochondrion, magnesium chelatase complex, chloroplast, chloroplast inner membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CobN/magnesium chelatase (InterPro:IPR003672), Magnesium-chelatase, subunit H (InterPro:IPR011771); Has 3665 Blast hits to 3123 proteins in 644 species: Archae - 281; Bacteria - 1903; Metazoa - 0; Fungi - 0; Plants - 92; Viruses - 0; Other Eukaryotes - 1389 (source: NCBI BLink).

NP_196867.1

GENOMES UNCOUPLED 5 (GUN5); FUNCTIONS IN: magnesium chelatase activity; INVOLVED IN: chlorophyll biosynthetic process, biosynthetic process; LOCATED IN: mitochondrion, magnesium chelatase complex, chloroplast, chloroplast inner membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CobN/magnesium chelatase (InterPro:IPR003672), Magnesium-chelatase, subunit H (InterPro:IPR011771); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

4387307..4392429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121366.4 → NP_196867.1 magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_196867.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DI09, B9DI10, Q39049, Q8RY14, Q9FNB0

UniProtKB/TrEMBL

A0A178U9Q0, A0A5S9Y4N1

Conserved Domains (1) summary

PLN03069
Location:56 → 1260

PLN03069; magnesiumprotoporphyrin-IX chelatase subunit H; Provisional
NM_001085109.1 → NP_001078578.1 magnesium-chelatase subunit chlH, chloroplast, putative / Mg-protoporphyrin IX chelatase, putative (CHLH) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078578.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MR05

Conserved Domains (3) summary

PLN03069
Location:56 → 1263

PLN03069; magnesiumprotoporphyrin-IX chelatase subunit H; Provisional

pfam02514
Location:244 → 1258

CobN-Mg_chel; CobN/Magnesium Chelatase

pfam11965
Location:79 → 240

DUF3479; Domain of unknown function (DUF3479)