PRR5 two-component response regulator-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PRR5
Official Full Name: two-component response regulator-like protein
Primary source: TAIR:AT5G24470
Locus tag: AT5G24470
See related: Araport:AT5G24470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: APRR5; pseudo-response regulator 5; T31K7.5; T31K7_5
Summary: Encodes a pseudo-response regulator whose mutation affects various circadian-associated biological events such as flowering time in the long-day photoperiod conditions, red light sensitivity of seedlings during early photomorphogenesis, and the period of free-running rhythms of certain clock-controlled genes including CCA1 and APRR1/TOC1 in constant white light. Acts as transcriptional repressor of CCA1 and LHY.
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Genomic context

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See PRR5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 6

Sequence:: Chromosome: 5; NC_003076.8 (8356204..8358546, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZTL regulates thermomorphogenesis through TOC1 and PRR5.
Title: ZTL regulates thermomorphogenesis through TOC1 and PRR5.
The Arabidopsis circadian clock protein PRR5 interacts with and stimulates ABI5 to modulate abscisic acid signaling during seed germination.
Title: The Arabidopsis circadian clock protein PRR5 interacts with and stimulates ABI5 to modulate abscisic acid signaling during seed germination.
Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.
Title: Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.
Findings suggest that Pseudo Response Regulators (PRRs)- Tandem Zinc Finger 1 (TZF1)- Target Of Rapamycin (TOR) signaling modulates root meristem cell proliferation by integrating both transcriptional and post-transcriptional regulatory mechanisms.
Title: PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis.
Data report that COR27 and COR28 bind to the chromatin of TOC1 and PRR5 to repress their transcription, suggesting that their effects on rhythms are in part due to their regulation of TOC1 and PRR5 These data demonstrate that blue light and low temperature-regulated COR27 and COR28 regulate the circadian clock as well as freezing tolerance and flowering time.
Title: Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock.
Direct binding by CCA1 in the morning provides strong repression of PRR5, and repression by CCA1 also temporally regulates an evening-expressed gene set that includes PRR5.
Title: Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock.
LNK1 is a transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 through recruitment to their promoters via interaction with bona fide DNA binding proteins such as RVE4 and RVE8.
Title: LNK1 and LNK2 are transcriptional coactivators in the Arabidopsis circadian oscillator.
Expression analyses of shade avoidance response (S.A.R)-related genes suggested that PRR5 functions as a repressor of S.A.R. Analyses of leaves under different light condition revealed that PRR5 is involved in the inhibition of leaf expansion in S.A.R.
Title: The unique function of the Arabidopsis circadian clock gene PRR5 in the regulation of shade avoidance response.
Transcriptional co-regulators PRR9, PRR7 and PRR5 inhibit morning loops LHY and CCA1 expression by binding to their promoters
Title: A Bayesian approach for parameter estimation in the extended clock gene circuit of Arabidopsis thaliana.
the promoter activity of A. thaliana core clock genes CCA1 and PRR5 in heterologous L. japonicus cells
Title: Molecular mechanisms of circadian rhythm in Lotus japonicus and Arabidopsis thaliana are sufficiently compatible to regulate heterologous core clock genes robustly.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_122355.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphorelay response regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in cytokinin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within photomorphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to far red light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to red light	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: two-component response regulator-like protein

NP_568446.2

pseudo-response regulator 5 (PRR5); CONTAINS InterPro DOMAIN/s: CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), CCT domain (InterPro:IPR010402); BEST Arabidopsis thaliana protein match is: pseudo-response regulator 9 (TAIR:AT2G46790.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8356204..8358546 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_122355.4 → NP_568446.2 two-component response regulator-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4KH52, Q6LA42, Q9FGE3

UniProtKB/TrEMBL

A0A5S9Y7F1, A0A654G3T3

Conserved Domains (3) summary

PRK10365
Location:50 → 278

PRK10365; sigma-54-dependent response regulator transcription factor ZraR

pfam06203
Location:509 → 551

CCT; CCT motif

cd17582
Location:52 → 155

psREC_PRR; pseudo receiver domain of pseudo-response regulators