U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RGF6 root meristem growth factor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827350, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RGF6
    Official Full Name
    root meristem growth factor
    Primary source
    TAIR:AT4G16515
    Locus tag
    AT4G16515
    See related
    Araport:AT4G16515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLE-like 6; CLEL 6; GLV1; GOLVEN 1; root meristem growth factor 6
    Summary
    Encodes a root meristem growth factor (RGF). Belongs to a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation. Members of this family include: At5g60810 (RGF1), At1g13620 (RGF2), At2g04025 (RGF3), At3g30350 (RGF4), At5g51451 (RGF5), At4g16515 (RGF6), At3g02240 (RGF7), At2g03830 (RGF8) and At5g64770 (RGF9).
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RGF6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (9305166..9305845, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene Cystatin/monellin superfamily protein Neighboring gene YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Neighboring gene Ubiquitin-like superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sulfopeptide CLEL6 inhibits anthocyanin biosynthesis in Arabidopsis thaliana. Bühler E, et al. Plant Physiol, 2023 Aug 31. PMID 37254811
    2. The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway. Stührwohldt N, et al. Elife, 2020 Apr 16. PMID 32297855, Free PMC Article
    3. The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation. Ghorbani S, et al. J Exp Bot, 2016 Aug. PMID 27315833, Free PMC Article
    4. GOLVEN secretory peptides regulate auxin carrier turnover during plant gravitropic responses. Whitford R, et al. Dev Cell, 2012 Mar 13. PMID 22421050
    5. CLE-like (CLEL) peptides control the pattern of root growth and lateral root development in Arabidopsis. Meng L, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307643, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sulfopeptide CLEL6 inhibits anthocyanin biosynthesis in Arabidopsis thaliana.
      Title: Sulfopeptide CLEL6 inhibits anthocyanin biosynthesis in Arabidopsis thaliana.
    2. The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway.
      Title: The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway.
    3. The GLV1 precursor is a direct subtilase substrate. The elimination of the in vitro subtilase recognition sites through alanine substitution suppressed the GLV1 gain-of-function phenotype in vivo. The protease inhibitor Serpin1 bound to SBT6.1 and inhibited the cleavage of GLV1 precursors by the protease.
      Title: The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_117750.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of asymmetric cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lateral root development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of root meristem growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of root morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    root meristem growth factor
    NP_567503.1
    • root meristem growth factor 6 (RGF6); FUNCTIONS IN: molecular_function unknown; LOCATED IN: endomembrane system; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 10 growth stages; Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9305166..9305845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341107.1 → NP_001328305.1  root meristem growth factor [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B471

    2. NM_117750.3 → NP_567503.1  root meristem growth factor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93VK8
      UniProtKB/TrEMBL
      A0A178UXF5, A0A5S9XT95
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93VK8.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.