Zeb2 zinc finger E-box binding homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zeb2provided by MGI
Official Full Name: zinc finger E-box binding homeobox 2provided by MGI
Primary source: MGI:MGI:1344407
See related: Ensembl:ENSMUSG00000026872 AllianceGenome:MGI:1344407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SIP1; Zfx1b; Zfhx1b; Zfxh1b; 9130203F04Rik; D130016B08Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; positive regulation of axonogenesis; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 11.4), CNS E18 (RPKM 9.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 27.31 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (44873523..45007378, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (44983512..45117442, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Title: N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
ABCs begin with ZEB2.
Title: ABCs begin with ZEB2.
Zeb2 drives the formation of CD11c[+] atypical B cells to sustain germinal centers that control persistent infection.
Title: Zeb2 drives the formation of CD11c(+) atypical B cells to sustain germinal centers that control persistent infection.
The transcription factor ZEB2 drives the formation of age-associated B cells.
Title: The transcription factor ZEB2 drives the formation of age-associated B cells.
The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.
Title: The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.
miR-147a targets ZEB2 to regulate ox-LDL-induced monocyte adherence to HUVECs, atherosclerotic plaque formation, and stability in atherosclerosis.
Title: miR-147a targets ZEB2 to regulate ox-LDL-induced monocyte adherence to HUVECs, atherosclerotic plaque formation, and stability in atherosclerosis.
Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration.
Title: Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration.
Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome.
Title: Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome.
Long noncoding RNA MALAT1 inhibition attenuates sepsis-induced acute lung injury through modulating the miR-129-5p/PAX6/ZEB2 axis.
Title: Long noncoding RNA MALAT1 inhibition attenuates sepsis-induced acute lung injury through modulating the miR-129-5p/PAX6/ZEB2 axis.
Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.
Title: Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zeb2 (e-PCR), detects polymorphism
- UniSTS:546057

AU048745 (e-PCR)
- UniSTS:145195

RH98161 (e-PCR)
- UniSTS:87935

STS-F02845 (e-PCR)
- UniSTS:38016

SHGC-35092 (e-PCR)
- UniSTS:35732

Zeb2 (e-PCR), detects polymorphism
- UniSTS:275879

Zeb2 (e-PCR), detects polymorphism
- UniSTS:275880

Zeb2 (e-PCR), detects polymorphism
- UniSTS:275881

RH141197 (e-PCR)
- UniSTS:223193

RH142396 (e-PCR)
- UniSTS:231643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell proliferation in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corticospinal tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in fibroblast activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammillary axonal complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanin biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in positive regulation of melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myofibroblast contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myofibroblast cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxygen-glucose deprivation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger E-box-binding homeobox 2

Names: smad-interacting protein 1; zinc finger homeobox protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289521.2 → NP_001276450.1 zinc finger E-box-binding homeobox 2

See identical proteins and their annotated locations for NP_001276450.1

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Related

ENSMUSP00000134747.2, ENSMUST00000177302.8

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain
NM_001355288.2 → NP_001342217.1 zinc finger E-box-binding homeobox 2

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Related

ENSMUSP00000134849.2, ENSMUST00000176438.9

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain
NM_001355289.2 → NP_001342218.1 zinc finger E-box-binding homeobox 2

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain
NM_001355290.2 → NP_001342219.1 zinc finger E-box-binding homeobox 2

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain
NM_001355291.2 → NP_001342220.1 zinc finger E-box-binding homeobox 2

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Related

ENSMUSP00000028229.8, ENSMUST00000028229.13

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain
NM_015753.5 → NP_056568.2 zinc finger E-box-binding homeobox 2

See identical proteins and their annotated locations for NP_056568.2

Status: VALIDATED

Source sequence(s)

AL929120, AL935127

Consensus CDS

CCDS16020.1

UniProtKB/Swiss-Prot

Q6P9M5, Q9R0G7

UniProtKB/TrEMBL

H9H9S3, Q3URW5

Related

ENSMUSP00000069685.5, ENSMUST00000068415.11

Conserved Domains (4) summary

cd00086
Location:653 → 695

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1001 → 1021

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:282 → 304

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:296 → 319

zf-H2C2_2; Zinc-finger double domain