U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Abcc2 ATP-binding cassette, sub-family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 12780, updated on 13-Jan-2025

    Summary

    Official Symbol
    Abcc2provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family member 2provided by MGI
    Primary source
    MGI:MGI:1352447
    See related
    Ensembl:ENSMUSG00000025194 AllianceGenome:MGI:1352447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrp2; cMRP; Abc30; Cmoat
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver adult (RPKM 39.0), kidney adult (RPKM 24.8) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcc2 in Genome Data Viewer
    Location:
    19 C3; 19 36.67 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43770747..43826771)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43782308..43838332)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene STARR-positive B cell enhancer ABC_E11677 Neighboring gene cytochrome c oxidase assembly protein 15 Neighboring gene STARR-positive B cell enhancer ABC_E5703 Neighboring gene cutC copper transporter Neighboring gene STARR-seq mESC enhancer starr_46204 Neighboring gene predicted gene 10768 Neighboring gene dynamin binding protein Neighboring gene predicted gene, 24400

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process  
    involved_in benzylpenicillin metabolic process  
    involved_in bile acid and bile salt transport  
    involved_in bile acid and bile salt transport  
    involved_in bilirubin transport  
    involved_in bilirubin transport  
    involved_in canalicular bile acid transport  
    involved_in detoxification of mercury ion  
    involved_in intracellular chloride ion homeostasis  
    involved_in leukotriene transport  
    involved_in leukotriene transport  
    involved_in mercury ion transport  
    involved_in negative regulation of gene expression  
    involved_in organic anion transport  
    involved_in prostaglandin transport  
    involved_in response to estrogen  
    involved_in response to xenobiotic stimulus  
    involved_in thyroid hormone transport  
    involved_in transepithelial transport  
    involved_in transmembrane transport  
    involved_in xenobiotic catabolic process  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane  
    involved_in xenobiotic export from cell  
    involved_in xenobiotic export from cell  
    involved_in xenobiotic transmembrane transport  
    involved_in xenobiotic transmembrane transport  
    involved_in xenobiotic transport across blood-brain barrier  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in brush border membrane  
    located_in cell surface  
    located_in cell surface  
    located_in intercellular canaliculus PubMed 
    located_in intracellular canaliculus  
    located_in membrane PubMed 
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 2
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
    canalicular multispecific organic anion transporter 1
    multidrug resistance protein 2
    multidrug resistance-associated protein 2
    NP_038834.2
    XP_006526688.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013806.2NP_038834.2  ATP-binding cassette sub-family C member 2

      See identical proteins and their annotated locations for NP_038834.2

      Status: VALIDATED

      Source sequence(s)
      AC132251, AC141888, AF282773
      Consensus CDS
      CCDS29838.1
      UniProtKB/Swiss-Prot
      Q8VI46, Q8VI47
      UniProtKB/TrEMBL
      Q9JIH8
      Related
      ENSMUSP00000026208.5, ENSMUST00000026208.6
      Conserved Domains (1) summary
      TIGR00957
      Location:101535
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43770747..43826771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526625.4XP_006526688.1  ATP-binding cassette sub-family C member 2 isoform X1

      UniProtKB/TrEMBL
      Q9JIH8
      Conserved Domains (1) summary
      TIGR00957
      Location:171487
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    External link. Please review our privacy policy.