Eef1akmt1 EEF1A alpha lysine methyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1akmt1provided by MGI
Official Full Name: EEF1A alpha lysine methyltransferase 1provided by MGI
Primary source: MGI:MGI:1915293
See related: Ensembl:ENSMUSG00000021951 AllianceGenome:MGI:1915293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: N6amt2; Ayu21-96; GtAyu21-96; 2510005D08Rik; Gt(pU21)96Imeg
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytoplasm. Orthologous to human EEF1AKMT1 (EEF1A lysine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 13.2), placenta adult (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 30.1 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (57787052..57809039, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (57549595..57571582, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EEF1A lysine methyltransferase 1

Names: Gt(Ayu21)96Imeg; N-6 adenine-specific DNA methyltransferase 2 (putative); eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1; n(6)-adenine-specific DNA methyltransferase 2; protein-lysine N-methyltransferase N6amt2

NP_080802.2

EC 2.1.1.-

XP_006519546.1

EC 2.1.1.-

XP_036014727.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026526.3 → NP_080802.2 EEF1A lysine methyltransferase 1

Status: VALIDATED

Source sequence(s)

AC154675

Consensus CDS

CCDS27157.2

UniProtKB/Swiss-Prot

Q9CQR0, Q9CY45

UniProtKB/TrEMBL

A0A0D2X7Z2

Related

ENSMUSP00000159159.2, ENSMUST00000239099.2

Conserved Domains (1) summary

pfam10237
Location:49 → 161

N6-adenineMlase; Probable N6-adenine methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

57787052..57809039 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158834.1 → XP_036014727.1 EEF1A lysine methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q9CQR0, Q9CY45

UniProtKB/TrEMBL

A0A0D2X7Z2

Conserved Domains (1) summary

pfam10237
Location:49 → 161

N6-adenineMlase; Probable N6-adenine methyltransferase
XM_006519483.4 → XP_006519546.1 EEF1A lysine methyltransferase 1 isoform X1

UniProtKB/Swiss-Prot

Q9CQR0, Q9CY45

UniProtKB/TrEMBL

A0A0D2X7Z2

Conserved Domains (1) summary

pfam10237
Location:49 → 161

N6-adenineMlase; Probable N6-adenine methyltransferase