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    Lrp2bp Lrp2 binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrp2bpprovided by RGD
    Official Full Name
    Lrp2 binding proteinprovided by RGD
    Primary source
    RGD:1305896
    See related
    EnsemblRapid:ENSRNOG00000011178 AllianceGenome:RGD:1305896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305896
    Summary
    Predicted to be located in cytoplasm. Orthologous to human LRP2BP (LRP2 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 76.6), Thymus (RPKM 10.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrp2bp in Genome Data Viewer
    Location:
    16q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52976005..53001952, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46241554..46269221, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49437373..49463100, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 97 Neighboring gene sorting nexin 25 Neighboring gene U6 spliceosomal RNA Neighboring gene ankyrin repeat domain 37 Neighboring gene UFM1-specific peptidase 2 Neighboring gene cilia and flagella associated protein 96 Neighboring gene coiled-coil domain containing 110

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LRP2-binding protein
    Names
    low density lipoprotein receptor-related protein 2 binding protein
    megalin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017443.1 → NP_001017443.1  LRP2-binding protein

      See identical proteins and their annotated locations for NP_001017443.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092575
      UniProtKB/Swiss-Prot
      Q569C2
      UniProtKB/TrEMBL
      A6JPP6, G3V9B8
      Related
      ENSRNOP00000041732.3, ENSRNOT00000041617.5
      Conserved Domains (3) summary
      smart00671
      Location:207 → 241
      SEL1; Sel1-like repeats
      COG0790
      Location:58 → 253
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:151 → 184
      SLR; SLR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52976005..53001952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253141.5 → XP_006253203.1  LRP2-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006253203.1

      UniProtKB/TrEMBL
      A0A8I6AIU2, A0A8I6G913, A6JPP5
      Related
      ENSRNOP00000088410.1, ENSRNOT00000106127.2
      Conserved Domains (3) summary
      smart00671
      Location:313 → 347
      SEL1; Sel1-like repeats
      COG0790
      Location:75 → 270
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:125 → 161
      SLR; SLR repeat [structural motif]

    2. XM_006253143.4 → XP_006253205.1  LRP2-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006253205.1

      UniProtKB/TrEMBL
      A0A8I6AIU2, A0A8I6G913, A6JPP5
      Conserved Domains (3) summary
      smart00671
      Location:313 → 347
      SEL1; Sel1-like repeats
      COG0790
      Location:75 → 270
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:125 → 161
      SLR; SLR repeat [structural motif]

    3. XM_039094382.2 → XP_038950310.1  LRP2-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6G913, A6JPP5
      Conserved Domains (3) summary
      smart00671
      Location:275 → 309
      SEL1; Sel1-like repeats
      COG0790
      Location:30 → 232
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:130 → 163
      SLR; SLR repeat [structural motif]

    4. XM_039094381.2 → XP_038950309.1  LRP2-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIU2, A0A8I6G913, A6JPP5
      Conserved Domains (3) summary
      smart00671
      Location:313 → 347
      SEL1; Sel1-like repeats
      COG0790
      Location:75 → 270
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:125 → 161
      SLR; SLR repeat [structural motif]

    5. XM_039094383.2 → XP_038950311.1  LRP2-binding protein isoform X3

      Conserved Domains (3) summary
      smart00671
      Location:181 → 215
      SEL1; Sel1-like repeats
      COG0790
      Location:18 → 138
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:36 → 69
      SLR; SLR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569C2.1 GenPept UniProtKB/Swiss-Prot:Q569C2

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