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    Rpia ribose 5-phosphate isomerase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpiaprovided by RGD
    Official Full Name
    ribose 5-phosphate isomerase Aprovided by RGD
    Primary source
    RGD:1311377
    See related
    EnsemblRapid:ENSRNOG00000005576 AllianceGenome:RGD:1311377
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables monosaccharide binding activity and ribose-5-phosphate isomerase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 188.8), Thymus (RPKM 159.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpia in Genome Data Viewer
    Location:
    4q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (104282081..104307732, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (102723712..102749374, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (98568028..98593664, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 2, pseudogene 1 Neighboring gene Ig kappa chain V-III region MOPC 321-like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102549525 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathy. Huck JH, et al. Am J Hum Genet, 2004 Apr. PMID 14988808, Free PMC Article
    2. The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa. Apel TW, et al. Gene, 1995 Apr 24. PMID 7758956
    3. The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats. Casazza JP, et al. J Biol Chem, 1986 Jan 15. PMID 3079759
    4. A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis. Veech RL. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721358, Free PMC Article
    5. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C, et al. J Biol Chem, 1988 Sep 15. PMID 2843500

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose-5-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose-5-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose-5-phosphate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-ribose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribose-5-phosphate isomerase
    NP_001102102.1
    XP_006236690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108632.1 → NP_001102102.1  ribose-5-phosphate isomerase

      See identical proteins and their annotated locations for NP_001102102.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473957
      UniProtKB/TrEMBL
      A6IA59, D4A7L6
      Related
      ENSRNOP00000007927.4, ENSRNOT00000007927.7
      Conserved Domains (1) summary
      cd01398
      Location:74 → 291
      RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      104282081..104307732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236628.5 → XP_006236690.1  ribose-5-phosphate isomerase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AS52
      Related
      ENSRNOP00000097607.1, ENSRNOT00000094761.2
      Conserved Domains (1) summary
      cd01398
      Location:74 → 271
      RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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