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    Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gbf1provided by RGD
    Official Full Name
    golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by RGD
    Primary source
    RGD:1307160
    See related
    EnsemblRapid:ENSRNOG00000026048 AllianceGenome:RGD:1307160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307160
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Located in Golgi stack; endoplasmic reticulum lumen; and peroxisome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 169.8), Heart (RPKM 139.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gbf1 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254959784..255088479)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245018535..245147052)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265904616..266033107)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3 Neighboring gene ATP synthase membrane subunit g, pseudogene 12 Neighboring gene uncharacterized LOC134484079 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 7 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene uncharacterized LOC134484075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1. García-Mata R, et al. Mol Biol Cell, 2003 Jun. PMID 12808027, Free PMC Article
    2. GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat. Kawamoto K, et al. Traffic, 2002 Jul. PMID 12047556
    3. AMPK phosphorylates GBF1 for mitotic Golgi disassembly. Mao L, et al. J Cell Sci, 2013 Mar 15. PMID 23418352
    4. Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Zhao X, et al. Mol Biol Cell, 2002 Jan. PMID 11809827, Free PMC Article
    5. Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking. Szul T, et al. J Cell Sci, 2007 Nov 15. PMID 17956946

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum-Golgi intermediate compartment organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of monopolar cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
    Names
    golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1
    golgi-specific brefeldin A-resistance factor 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191634.1 → NP_001178563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (3) summary
      COG5307
      Location:483 → 1162
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:699 → 884
      Sec7; Sec7 domain
      pfam12783
      Location:400 → 545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254959784..255088479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231500.5 → XP_006231562.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A6JHL5
      Related
      ENSRNOP00000038037.7, ENSRNOT00000036156.7
      Conserved Domains (3) summary
      COG5307
      Location:484 → 1163
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700 → 885
      Sec7; Sec7 domain
      pfam12783
      Location:401 → 546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    2. XM_006231501.5 → XP_006231563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9

      UniProtKB/TrEMBL
      A6JHL5, F1M8X9
      Conserved Domains (3) summary
      COG5307
      Location:484 → 1163
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:700 → 885
      Sec7; Sec7 domain
      pfam12783
      Location:401 → 546
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    3. XM_006231502.5 → XP_006231564.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X10

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (3) summary
      COG5307
      Location:483 → 1162
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:699 → 884
      Sec7; Sec7 domain
      pfam12783
      Location:400 → 545
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    4. XM_039080486.2 → XP_038936414.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (4) summary
      PHA03247
      Location:1756 → 1886
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:510 → 1029
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:726 → 911
      Sec7; Sec7 domain
      pfam12783
      Location:427 → 572
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    5. XM_006231496.5 → XP_006231558.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:733 → 918
      Sec7; Sec7 domain
      pfam12783
      Location:434 → 579
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    6. XM_006231497.5 → XP_006231559.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:732 → 917
      Sec7; Sec7 domain
      pfam12783
      Location:433 → 578
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    7. XM_039080492.2 → XP_038936420.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (4) summary
      PHA03247
      Location:1755 → 1885
      PHA03247; large tegument protein UL36; Provisional
      COG5307
      Location:509 → 1028
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:725 → 910
      Sec7; Sec7 domain
      pfam12783
      Location:426 → 571
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    8. XM_063264977.1 → XP_063121047.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      A6JHL5

    9. XM_063264979.1 → XP_063121049.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      A6JHL5
      Related
      ENSRNOP00000102549.1, ENSRNOT00000149376.1

    10. XM_006231498.5 → XP_006231560.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      A6JHL5
      Conserved Domains (2) summary
      pfam01369
      Location:733 → 918
      Sec7; Sec7 domain
      pfam12783
      Location:434 → 579
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    11. XM_063264948.1 → XP_063121018.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

      UniProtKB/TrEMBL
      A6JHL5

    12. XM_063264959.1 → XP_063121029.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A6JHL5
    Nucleotide Protein Strain
    Heading Accession and Version

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