Fkbp3 FK506 binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp3provided by MGI
Official Full Name: FK506 binding protein 3provided by MGI
Primary source: MGI:MGI:1353460
See related: Ensembl:ENSMUSG00000020949 AllianceGenome:MGI:1353460
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 25kDa; FKBP-3; FKBP25
Summary: Predicted to enable RNA polymerase II CTD heptapeptide repeat P3 isomerase activity and RNA polymerase II CTD heptapeptide repeat P6 isomerase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human FKBP3 (FKBP prolyl isomerase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 104.7), CNS E14 (RPKM 69.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 27.21 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (65109206..65120712, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (65062432..65073938, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation.
Title: FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation.
findings reveal that the nuclear import of FKBP25 and binding with 60S ribosomal protein L7a are protective stress responses to ischemia/nitrosaive stress injury.
Title: Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury.
targets of FKBP25 and its complex with rapamycin
Title: Diversified targets of FKBP25 and its complex with rapamycin.
analysis of the expression pattern of the Fkbp25 gene during cerebral cortical neurogenesis
Title: Molecular cloning and expression pattern of the Fkbp25 gene during cerebral cortical neurogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fkbp3 (e-PCR), detects polymorphism
- UniSTS:506894

RH126701 (e-PCR)
- UniSTS:208810

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP3

Names: 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; PPIase FKBP3; immunophilin FKBP25; rapamycin-selective 25 kDa immunophilin; rotamase

NP_038930.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.