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    Mmp14 matrix metallopeptidase 14 (membrane-inserted) [ Mus musculus (house mouse) ]

    Gene ID: 17387, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mmp14provided by MGI
    Official Full Name
    matrix metallopeptidase 14 (membrane-inserted)provided by MGI
    Primary source
    MGI:MGI:101900
    See related
    Ensembl:ENSMUSG00000000957 AllianceGenome:MGI:101900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sabe; MMP-X1; MT1-MMP; MT-MMP-1
    Summary
    This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in ovary adult (RPKM 116.4), limb E14.5 (RPKM 100.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mmp14 in Genome Data Viewer
    Location:
    14 C2; 14 27.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54669055..54679913)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54431598..54442456)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene oxidase assembly 1-like Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 Neighboring gene STARR-seq mESC enhancer starr_36728 Neighboring gene STARR-positive B cell enhancer ABC_E3115 Neighboring gene STARR-seq mESC enhancer starr_36729 Neighboring gene STARR-seq mESC enhancer starr_36730 Neighboring gene STARR-seq mESC enhancer starr_36733 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55067911-55068211 Neighboring gene STARR-seq mESC enhancer starr_36736 Neighboring gene predicted gene, 24424 Neighboring gene STARR-positive B cell enhancer ABC_E8559 Neighboring gene STARR-positive B cell enhancer ABC_E5436 Neighboring gene low-density lipoprotein receptor-related protein 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5) 
    • Spontaneous (1) 
    • Targeted (13)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within collagen catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within craniofacial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within endochondral ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of GDF15-GFRAL signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of GDF15-GFRAL signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to odorant IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zymogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in macropinosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-14
    Names
    Membrane type 1-MMP
    matrix metalloproteinase 14 (membrane-inserted)
    membrane-type-1 matrix metalloproteinase
    type 1 matrix metalloprotease 14
    NP_032634.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008608.4NP_032634.3  matrix metalloproteinase-14 preproprotein

      See identical proteins and their annotated locations for NP_032634.3

      Status: REVIEWED

      Source sequence(s)
      AC206013, AK165014, W75261
      Consensus CDS
      CCDS36922.1
      UniProtKB/Swiss-Prot
      O08645, O35369, P53690, Q8BTX2
      UniProtKB/TrEMBL
      Q3TQH0
      Related
      ENSMUSP00000087119.5, ENSMUST00000089688.6
      Conserved Domains (5) summary
      cd00094
      Location:316508
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:118284
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:118284
      Peptidase_M10; Matrixin
      pfam01471
      Location:3688
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:560582
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54669055..54679913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)