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    Ccdc85b coiled-coil domain containing 85B [ Mus musculus (house mouse) ]

    Gene ID: 240514, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccdc85bprovided by MGI
    Official Full Name
    coiled-coil domain containing 85Bprovided by MGI
    Primary source
    MGI:MGI:2147607
    See related
    Ensembl:ENSMUSG00000095098 AllianceGenome:MGI:2147607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable delta-catenin binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human CCDC85B (coiled-coil domain containing 85B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.3), lung adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ccdc85b in Genome Data Viewer
    Location:
    19 A; 19 4.33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5503191..5507591, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5453163..5457563, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25432 Neighboring gene predicted gene, 31070 Neighboring gene fos-like antigen 1 Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Clone Names

    • MGC67311

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 85B
    Names
    delta-interacting protein A homolog
    hepatitis delta antigen-interacting protein A homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243307.1NP_001230236.1  coiled-coil domain-containing protein 85B isoform 2

      See identical proteins and their annotated locations for NP_001230236.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment of the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC094592, BQ445696, BY124251, CK337075
      Consensus CDS
      CCDS89309.1
      UniProtKB/TrEMBL
      A0A494B9B6
      Related
      ENSMUSP00000157571.2, ENSMUST00000236881.2
    2. NM_198616.4NP_941018.1  coiled-coil domain-containing protein 85B isoform 1

      See identical proteins and their annotated locations for NP_941018.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC058411, BC094592, BY124251, CK337075
      Consensus CDS
      CCDS50357.1
      UniProtKB/Swiss-Prot
      Q6PDY0
      Related
      ENSMUSP00000137537.2, ENSMUST00000179549.3
      Conserved Domains (1) summary
      pfam10226
      Location:5178
      CCDC85; CCDC85 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5503191..5507591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)