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    Vps72 vacuolar protein sorting 72 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps72provided by RGD
    Official Full Name
    vacuolar protein sorting 72 homologprovided by RGD
    Primary source
    RGD:1306121
    See related
    EnsemblRapid:ENSRNOG00000021081 AllianceGenome:RGD:1306121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfl1
    Summary
    Predicted to enable histone binding activity and histone chaperone activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within somatic stem cell population maintenance. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Predicted to be active in nucleus. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 167.9), Brain (RPKM 129.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vps72 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185367329..185379199)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182678594..182690185)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196277961..196289549)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485649 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha Neighboring gene tropomodulin 4 Neighboring gene sodium channel modifier 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1. Latrick CM, et al. Nat Struct Mol Biol, 2016 Apr. PMID 26974126
    2. A functional screen to identify novel effectors of hematopoietic stem cell activity. Deneault E, et al. Cell, 2009 Apr 17. PMID 19379700, Free PMC Article
    3. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    4. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated protein 72 homolog
    Names
    transcription factor-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107695.1 → NP_001101165.1  vacuolar protein sorting-associated protein 72 homolog

      See identical proteins and their annotated locations for NP_001101165.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      UniProtKB/TrEMBL
      B1WC45, F7FDV0
      Related
      ENSRNOP00000028625.4, ENSRNOT00000028625.8
      Conserved Domains (2) summary
      pfam05764
      Location:7 → 216
      YL1; YL1 nuclear protein
      pfam08265
      Location:291 → 319
      YL1_C; YL1 nuclear protein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185367329..185379199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761302.4 → XP_008759524.1  vacuolar protein sorting-associated protein 72 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWK2
      Related
      ENSRNOP00000083429.1, ENSRNOT00000110220.2
      Conserved Domains (2) summary
      pfam04180
      Location:22 → 78
      LTV; Low temperature viability protein
      pfam05764
      Location:6 → 183
      YL1; YL1 nuclear protein
    Nucleotide Protein Strain
    Heading Accession and Version

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