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    Zfp157 zinc finger protein 157 [ Mus musculus (house mouse) ]

    Gene ID: 72154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp157provided by MGI
    Official Full Name
    zinc finger protein 157provided by MGI
    Primary source
    MGI:MGI:1919404
    See related
    Ensembl:ENSMUSG00000036898 AllianceGenome:MGI:1919404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Roma; mszf12; mszf23-1; 2610020C11Rik; A630094N24Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within lung alveolus development; mammary gland morphogenesis; and regulation of cell fate commitment. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and limb. Orthologous to human ZNF613 (zinc finger protein 613). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 5.4), CNS E14 (RPKM 5.4) and 22 other tissues See more
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    Genomic context

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    See Zfp157 in Genome Data Viewer
    Location:
    5 G2; 5 77.09 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138439721..138459162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138441458..138460900)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10874 Neighboring gene cytochrome P450, family 3, subfamily a, member 61, pseudogene 1 Neighboring gene predicted gene, 25525 Neighboring gene STARR-seq mESC enhancer starr_14666 Neighboring gene STARR-seq mESC enhancer starr_14667 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The KRAB domain zinc finger protein, Zfp157, is expressed in multiple tissues during mouse embryogenesis and in specific cells in adult mammary gland and skin. Oliver CH, et al. Genesis, 2013 Mar. PMID 23315963
    2. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Ho TLF, et al. Cell Rep, 2016 Apr 26. PMID 27149840, Free PMC Article
    3. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Oliver CH, et al. Genes Dev, 2012 May 15. PMID 22588720, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study explores the role of Zfp157 in alveologenesis and reveals that this transcriptional regulator controls the balance of luminal populations and is a critical mediator of Gata-3 signaling.
      Title: The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 157

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028130.3 → NP_082406.2  zinc finger protein 157

      See identical proteins and their annotated locations for NP_082406.2

      Status: VALIDATED

      Source sequence(s)
      AI789072, BC059261
      Consensus CDS
      CCDS39345.1
      UniProtKB/TrEMBL
      Q6PCM4
      Related
      ENSMUSP00000083018.6, ENSMUST00000085856.12
      Conserved Domains (6) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:181 → 535
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:366 → 388
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138439721..138459162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165513.1 → XP_036021406.1  zinc finger protein 157 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:88 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006504625.3 → XP_006504688.1  zinc finger protein 157 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:19 → 79
      KRAB; krueppel associated box
      COG5048
      Location:196 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:396 → 416
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036165512.1 → XP_036021405.1  zinc finger protein 157 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:88 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036165510.1 → XP_036021403.1  zinc finger protein 157 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:88 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006504626.5 → XP_006504689.1  zinc finger protein 157 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:88 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036165511.1 → XP_036021404.1  zinc finger protein 157 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:88 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036165515.1 → XP_036021408.1  zinc finger protein 157 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:68 → 396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_006504627.4 → XP_006504690.1  zinc finger protein 157 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:68 → 396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:268 → 288
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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