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    Cldn34c1 claudin 34C1 [ Mus musculus (house mouse) ]

    Gene ID: 73061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cldn34c1provided by MGI
    Official Full Name
    claudin 34C1provided by MGI
    Primary source
    MGI:MGI:1920311
    See related
    Ensembl:ENSMUSG00000079450 AllianceGenome:MGI:1920311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110007F17Rik
    Summary
    Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN34 (claudin 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 3.0), CNS E14 (RPKM 2.6) and 21 other tissues See more
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    Genomic context

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    See Cldn34c1 in Genome Data Viewer
    Location:
    X E3; X 49.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (122013220..122055351)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (123103523..123145654)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 133, member B pseudogene Neighboring gene STARR-seq mESC enhancer starr_47876 Neighboring gene nucleolin pseudogene Neighboring gene STARR-seq mESC enhancer starr_47877 Neighboring gene STARR-seq mESC enhancer starr_47878 Neighboring gene STARR-seq mESC enhancer starr_47880 Neighboring gene amplified spermatogenic transcripts X encoded 6 Neighboring gene serine-rich, secreted, X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    claudin 34C1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310652.1 → NP_001297581.1  claudin 34C1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AK032219, BX521033, BY582041
      UniProtKB/TrEMBL
      Q9CXT3

    2. NM_001310654.1 → NP_001297583.1  claudin 34C1 isoform 3

      See identical proteins and their annotated locations for NP_001297583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK032219, BY582041
      Consensus CDS
      CCDS81167.1
      UniProtKB/TrEMBL
      A0A991EL07, Q8CCR8, Q9CXT3
      Related
      ENSMUSP00000108970.2, ENSMUST00000113343.8

    3. NM_028426.2 → NP_082702.1  claudin 34C1 isoform 1

      See identical proteins and their annotated locations for NP_082702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the isoform 1.
      Source sequence(s)
      AK032219, BC027572, BY582041
      Consensus CDS
      CCDS53178.1
      UniProtKB/TrEMBL
      Q8K193, Q9CXT3
      Related
      ENSMUSP00000108975.2, ENSMUST00000113348.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      122013220..122055351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247709.4 → XP_011246011.1  claudin 34C1 isoform X1

      See identical proteins and their annotated locations for XP_011246011.1

      UniProtKB/TrEMBL
      Q8K193, Q9CXT3

    2. XM_036162108.1 → XP_036018001.1  claudin 34C1 isoform X2

      UniProtKB/TrEMBL
      A0A991EL07, Q8CCR8, Q9CXT3

    3. XM_036162107.1 → XP_036018000.1  claudin 34C1 isoform X1

      UniProtKB/TrEMBL
      Q8K193, Q9CXT3

    4. XM_036162106.1 → XP_036017999.1  claudin 34C1 isoform X1

      UniProtKB/TrEMBL
      Q8K193, Q9CXT3

    5. XM_006528410.4 → XP_006528473.1  claudin 34C1 isoform X2

      See identical proteins and their annotated locations for XP_006528473.1

      UniProtKB/TrEMBL
      A0A991EL07, Q8CCR8, Q9CXT3
    Nucleotide Protein Strain
    Heading Accession and Version

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