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    Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114490, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cited2provided by RGD
    Official Full Name
    Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2provided by RGD
    Primary source
    RGD:620112
    See related
    EnsemblRapid:ENSRNOG00000056940 AllianceGenome:RGD:620112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrg1
    Summary
    Predicted to enable several functions, including LBD domain binding activity; histone acetyltransferase binding activity; and transcription coregulator activity. Involved in several processes, including cellular senescence; negative regulation of cardiac muscle cell proliferation; and regulation of gene expression. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Used to study osteosarcoma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in atrial heart septal defect 8 and ventricular septal defect. Orthologous to human CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 358.4), Kidney (RPKM 299.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cited2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (14132303..14134746)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (12312426..12314869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (12823363..12825806)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546831 Neighboring gene uncharacterized LOC108349493 Neighboring gene uncharacterized LOC120098791 Neighboring gene uncharacterized LOC134484952 Neighboring gene uncharacterized LOC134484954 Neighboring gene uncharacterized LOC134484953

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Clone Names

    • MGC93288

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables LBD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adrenal cortex formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac neural crest cell development involved in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular senescence IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cranial nerve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of heart left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of left/right asymmetry in lateral mesoderm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of left/right symmetry ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within embryonic camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic heart tube left/right pattern formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in left/right axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in left/right pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lens morphogenesis in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nodal signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within pulmonary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of animal organ formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sex determination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sex determination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophectodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within uterus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cbp/p300-interacting transactivator 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053698.3NP_446150.1  cbp/p300-interacting transactivator 2

      See identical proteins and their annotated locations for NP_446150.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K7N2, Q99MA1
      Related
      ENSRNOP00000107079.1, ENSRNOT00000124538.1
      Conserved Domains (1) summary
      pfam04487
      Location:1269
      CITED

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      14132303..14134746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)