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    GlcNAc1pUT2 N-acetylglucosamine-1-phosphate uridylyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818066, updated on 14-Nov-2024

    Summary

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    Official Symbol
    GlcNAc1pUT2
    Official Full Name
    N-acetylglucosamine-1-phosphate uridylyltransferase 2
    Primary source
    TAIR:AT2G35020
    Locus tag
    AT2G35020
    See related
    Araport:AT2G35020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F19I3.25; F19I3_25; GLCNA.UT2; N-acetylglucosamine-1-phosphate uridylyltransferase 2
    Summary
    Encodes a protein that functions as an N-acetylglucosamine-1-phosphate uridylyltransferase that catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc). This is an essential precursor for glycolipid and glycoprotein synthesis and is also used for regulatory protein modification in signaling pathways. The enzyme can also catalyze the reverse reaction using both UDP-GlcNAc and the less common UDP-N-acetylgalactosamine as substrates. This enzyme can also act on glucose-1-phosphate to produce UDP-glucose.
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    Genomic context

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    See GlcNAc1pUT2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (14756511..14760709)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene thioredoxin O1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene urease accessory protein D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana. Chen YH, et al. Plant Cell Physiol, 2014 Nov. PMID 25231969
    2. Identification and characterization of a strict and a promiscuous N-acetylglucosamine-1-P uridylyltransferase in Arabidopsis. Yang T, et al. Biochem J, 2010 Sep 1. PMID 20557289
    3. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At2g35020 is required for gametogenesis and embryo development in Arabidopsis thaliana.
      Title: N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_129054.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine diphosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-N-acetylgalactosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within UDP-N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-alpha-D-glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylglucosamine-1-phosphate uridylyltransferase 2
    NP_181047.1
    • N-acetylglucosamine-1-phosphate uridylyltransferase 2 (GlcNAc1pUT2); CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: N-acetylglucosamine-1-phosphate uridylyltransferase 1 (TAIR:AT1G31070.2); Has 1547 Blast hits to 1541 proteins in 446 species: Archae - 0; Bacteria - 380; Metazoa - 421; Fungi - 279; Plants - 232; Viruses - 0; Other Eukaryotes - 235 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14756511..14760709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129054.4 → NP_181047.1  N-acetylglucosamine-1-phosphate uridylyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64765, Q5PNR7, Q8L9P4
      UniProtKB/TrEMBL
      A0A178VSP9, A0A5S9X406
      Conserved Domains (1) summary
      PLN02435
      Location:1 → 502
      PLN02435; probable UDP-N-acetylglucosamine pyrophosphorylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64765.1

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