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    SUVR5 histone-lysine N-methyltransferase SUVR5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816905, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUVR5
    Official Full Name
    histone-lysine N-methyltransferase SUVR5
    Primary source
    TAIR:AT2G23740
    Locus tag
    AT2G23740
    See related
    Araport:AT2G23740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F27L4.8; F27L4_8; SU(VAR)3-9-RELATED protein 5
    Summary
    Encodes a SET-domain protein SUVR5 that mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.
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    Genomic context

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    See SUVR5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (10097265..10103398)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transmembrane family 220 helix protein Neighboring gene BEL1-like homeodomain 4 Neighboring gene protein kinase family protein / peptidoglycan-binding LysM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner. Caro E, et al. PLoS Genet, 2012. PMID 23071452, Free PMC Article
    2. C2H2 zinc finger-SET histone methyltransferase is a plant-specific chromatin modifier. Krichevsky A, et al. Dev Biol, 2007 Mar 1. PMID 17224141, Free PMC Article
    3. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.
      Title: The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001202656.2
    NM_001335863.1
    NM_001335864.1
    NM_127937.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone H3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SUVR5
    NP_001189585.1
    • nucleic acid binding;sequence-specific DNA binding transcription factors;zinc ion binding; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, zinc ion binding, nucleic acid binding; INVOLVED IN: chromatin modification; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), SET domain (InterPro:IPR001214), Pre-SET domain (InterPro:IPR007728), Post-SET domain (InterPro:IPR003616), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 5 (TAIR:AT2G35160.1).
    NP_179954.2
    • nucleic acid binding;sequence-specific DNA binding transcription factors;zinc ion binding; FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, zinc ion binding, nucleic acid binding; INVOLVED IN: chromatin modification; LOCATED IN: nucleus, intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), SET domain (InterPro:IPR001214), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Post-SET domain (InterPro:IPR003616), Pre-SET domain (InterPro:IPR007728), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 5 (TAIR:AT2G35160.1); Has 5962 Blast hits to 5734 proteins in 461 species: Archae - 0; Bacteria - 386; Metazoa - 2995; Fungi - 515; Plants - 1025; Viruses - 0; Other Eukaryotes - 1041 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10097265..10103398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335861.1 → NP_001324207.1  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MA41, A0MA42, B9DGK7, C0Z2K8, O64827, O64828, O64829
      UniProtKB/TrEMBL
      A0A654EVI9
      Conserved Domains (2) summary
      cl40432
      Location:1124 → 1381
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam18868
      Location:737 → 862
      zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

    2. NM_001335862.1 → NP_001324206.1  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VRJ6, A0A1P8AZG6, A0A384KWC1, A0A654EVI9

    3. NM_001202656.2 → NP_001189585.1  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MA41, A0MA42, B9DGK7, C0Z2K8, O64827, O64828, O64829
      UniProtKB/TrEMBL
      A0A654EVI9
      Conserved Domains (2) summary
      cl40432
      Location:1124 → 1381
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam18868
      Location:737 → 862
      zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats

    4. NM_001335863.1 → NP_001324205.1  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VRJ6, A0A1P8AZG6, A0A384KWC1, A0A654EVI9

    5. NM_127937.2 → NP_179954.2  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179954.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EVI9, F4IMM1
      Conserved Domains (2) summary
      smart00317
      Location:1217 → 1350
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:1087 → 1209
      Pre-SET; Pre-SET motif

    6. NM_001335864.1 → NP_001324204.1  histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MA41, A0MA42, B9DGK7, C0Z2K8, O64827, O64828, O64829
      UniProtKB/TrEMBL
      A0A654EVI9
      Conserved Domains (2) summary
      cl40432
      Location:1124 → 1381
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam18868
      Location:737 → 862
      zf-C2H2_3rep; Zinc finger C2H2-type, 3 repeats
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64827.3

    Gene LinkOut

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