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    IPMI2 isopropylmalate isomerase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818912, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IPMI2
    Official Full Name
    isopropylmalate isomerase 2
    Primary source
    TAIR:AT2G43100
    Locus tag
    AT2G43100
    See related
    Araport:AT2G43100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATLEUD1; isopropylmalate isomerase 2; MFL8.14
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    Genomic context

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    See IPMI2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (17920647..17921844)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene P4H isoform 1 Neighboring gene Aconitase/3-isopropylmalate dehydratase protein Neighboring gene U3 containing 90S pre-ribosomal complex subunit Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation. Knill T, et al. Plant Mol Biol, 2009 Oct. PMID 19597944, Free PMC Article
    2. In Arabidopsis thaliana Substrate Recognition and Tissue- as Well as Plastid Type-Specific Expression Define the Roles of Distinct Small Subunits of Isopropylmalate Isomerase. Lächler K, et al. Front Plant Sci, 2020. PMID 32612621, Free PMC Article
    3. Functional specification of Arabidopsis isopropylmalate isomerases in glucosinolate and leucine biosynthesis. He Y, et al. Plant Cell Physiol, 2010 Sep. PMID 20663849
    4. The plastidic bile acid transporter 5 is required for the biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana. Gigolashvili T, et al. Plant Cell, 2009 Jun. PMID 19542295, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that the small subunit of isopropylmalate isomerase (IPMI SSU2 encoded by At2g43100) fusion protein IPMI SSU2:GFP was imported into chloroplasts.
      Title: Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_129871.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isopropylmalate isomerase 2
    NP_181838.1
    • isopropylmalate isomerase 2 (IPMI2); FUNCTIONS IN: hydro-lyase activity, 3-isopropylmalate dehydratase activity; INVOLVED IN: leucine biosynthetic process, metabolic process; LOCATED IN: plastid; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: 3-isopropylmalate dehydratase, small subunit-like (InterPro:IPR012305), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase-like core (InterPro:IPR015937); BEST Arabidopsis thaliana protein match is: Aconitase/3-isopropylmalate dehydratase protein (TAIR:AT2G43090.1); Has 8735 Blast hits to 8734 proteins in 2248 species: Archae - 359; Bacteria - 5628; Metazoa - 12; Fungi - 337; Plants - 71; Viruses - 0; Other Eukaryotes - 2328 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17920647..17921844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129871.3 → NP_181838.1  isopropylmalate isomerase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181838.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZW84
      UniProtKB/TrEMBL
      A0A178VZE1, A0A5S9X6L4, A0A7G2EIR7
      Conserved Domains (1) summary
      PLN00072
      Location:1 → 255
      PLN00072; 3-isopropylmalate isomerase/dehydratase small subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZW84.1

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