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    protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816524, updated on 18-Sep-2024

    Summary

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    Official Full Name
    protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein
    Primary source
    TAIR:AT2G20050
    Locus tag
    AT2G20050
    See related
    Araport:AT2G20050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T2G17.15; T2G17_15
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (8649434..8654819, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA-binding CRS1 / YhbY (CRM) domain-containing protein Neighboring gene RING/U-box superfamily protein Neighboring gene Ribosomal protein L4/L1 family Neighboring gene defensin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001202628.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein
    NP_001189557.1
    • protein serine/threonine phosphatases;protein kinases;catalytics;cAMP-dependent protein kinase regulators;ATP binding;protein serine/threonine phosphatases; FUNCTIONS IN: in 6 functions; INVOLVED IN: protein amino acid phosphorylation, protein amino acid dephosphorylation, regulation of protein amino acid phosphorylation; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), cAMP/cGMP-dependent protein kinase (InterPro:IPR002373), Serine/threonine-protein kinase domain (InterPro:IPR002290), Protein phosphatase 2C-related (InterPro:IPR001932), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein kinase, catalytic domain (InterPro:IPR000719), Cyclic nucleotide-binding-like (InterPro:IPR018490), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT3G06270.1).
    NP_179595.5
    • protein serine/threonine phosphatases;protein kinases;catalytics;cAMP-dependent protein kinase regulators;ATP binding;protein serine/threonine phosphatases; FUNCTIONS IN: cAMP-dependent protein kinase regulator activity, protein kinase activity, protein serine/threonine phosphatase activity, catalytic activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, protein amino acid dephosphorylation, N-terminal protein myristoylation, regulation of protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), cAMP/cGMP-dependent protein kinase (InterPro:IPR002373), Protein phosphatase 2C-related (InterPro:IPR001932), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein kinase, catalytic domain (InterPro:IPR000719), Cyclic nucleotide-binding-like (InterPro:IPR018490), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: Protein phosphatase 2C family protein (TAIR:AT3G06270.1); Has 64548 Blast hits to 63479 proteins in 2268 species: Archae - 40; Bacteria - 8440; Metazoa - 24888; Fungi - 7627; Plants - 9963; Viruses - 207; Other Eukaryotes - 13383 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8649434..8654819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127563.6 → NP_179595.5  protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179595.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5KQ16, B5KQ17, Q0WLT6, Q9SL76, Q9SL77
      UniProtKB/TrEMBL
      A0A5S9WZS6, A0A654F559
      Conserved Domains (3) summary
      cd00038
      Location:491 → 600
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00143
      Location:123 → 397
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      cl21453
      Location:797 → 1054
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001202628.1 → NP_001189557.1  protein phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189557.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F559, F4IUD7
      Conserved Domains (5) summary
      COG0664
      Location:485 → 622
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:491 → 597
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00143
      Location:123 → 397
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam00069
      Location:795 → 1035
      Pkinase; Protein kinase domain
      cl21453
      Location:794 → 1051
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SL76.2

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