U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BSU1 Serine/threonine protein phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838804, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BSU1
    Official Full Name
    Serine/threonine protein phosphatase family protein
    Primary source
    TAIR:AT1G03445
    Locus tag
    AT1G03445
    See related
    Araport:AT1G03445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BRI1 SUPPRESSOR 1; F21B7.7
    Summary
    encodes a serine#Aeithreonine protein phosphatase with an N-terminal Kelch-repeat domain, which is nuclear localized and expressed preferentially in elongating cells. Genetic evidence suggest that this gene plays a redundant role (along with other members of the same gene family) in modulating growth in response to brassinosteroid.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BSU1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    22
    Sequence:
    Chromosome: 1; NC_003070.9 (854410..859701, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene histidine-containing phosphotransfer factor 5 Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Kinase interacting (KIP1-like) family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis. Mora-García S, et al. Genes Dev, 2004 Feb 15. PMID 14977918, Free PMC Article
    2. BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling. Ren H, et al. PLoS Genet, 2019 Jan. PMID 30615605, Free PMC Article
    3. Predominant actions of cytosolic BSU1 and nuclear BIN2 regulate subcellular localization of BES1 in brassinosteroid signaling. Ryu H, et al. Mol Cells, 2010 Mar. PMID 20387035
    4. The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2. Kim TW, et al. Mol Cell, 2011 Aug 19. PMID 21855796, Free PMC Article
    5. Nucleocytoplasmic shuttling of BZR1 mediated by phosphorylation is essential in Arabidopsis brassinosteroid signaling. Ryu H, et al. Plant Cell, 2007 Sep. PMID 17873094, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we find that BSK3 upregulates BSU1 transcript and protein levels to activate BR signaling. BSK3 is broadly expressed and plays an important role in BR-mediated root growth, shoot growth, and organ separation. Together, our findings suggest that BSK3 may function as a scaffold protein to regulate BR signaling. The results of our studies provide new insights into early BR signaling mechanisms.
      Title: BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling.
    2. Cytoplasmic BSU1 mediated BES1 dephosphorylation & nuclear translocation, & it compromised the dwarf phenotype of bri1-5 better than nuclear BSU1 in transgenic plants.
      Title: Predominant actions of cytosolic BSU1 and nuclear BIN2 regulate subcellular localization of BES1 in brassinosteroid signaling.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brassinosteroid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine protein phosphatase family protein
    NP_171844.6
    • BRI1 SUPPRESSOR 1 (BSU1); FUNCTIONS IN: protein binding, protein serine/threonine phosphatase activity; INVOLVED IN: brassinosteroid mediated signaling pathway, regulation of protein localization; LOCATED IN: nucleus; EXPRESSED IN: sperm cell, male gametophyte, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Serine/threonine protein phosphatase, BSU1 (InterPro:IPR012391), Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Metallophosphoesterase (InterPro:IPR004843), Kelch repeat type 2 (InterPro:IPR011498), Kelch-type beta propeller (InterPro:IPR015915), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: BRI1 suppressor 1 (BSU1)-like 1 (TAIR:AT4G03080.1); Has 12351 Blast hits to 9811 proteins in 679 species: Archae - 82; Bacteria - 604; Metazoa - 4121; Fungi - 2161; Plants - 2580; Viruses - 7; Other Eukaryotes - 2796 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      854410..859701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100227.6 → NP_171844.6  Serine/threonine protein phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171844.6

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LR78
      UniProtKB/TrEMBL
      A0A178WIX8, A0A5S9SDH6
      Conserved Domains (3) summary
      PLN02193
      Location:26 → 294
      PLN02193; nitrile-specifier protein
      sd00038
      Location:31 → 92
      Kelch; KELCH repeat [structural motif]
      cl13995
      Location:456 → 757
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    2. NM_001331412.1 → NP_001321215.1  Serine/threonine protein phosphatase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ82, A0A5S9SDH6
      Conserved Domains (3) summary
      PLN02193
      Location:26 → 294
      PLN02193; nitrile-specifier protein
      sd00038
      Location:31 → 92
      Kelch; KELCH repeat [structural motif]
      cl13995
      Location:456 → 757
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LR78.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.