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    LOS2 Enolase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818226, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOS2
    Official Full Name
    Enolase
    Primary source
    TAIR:AT2G36530
    Locus tag
    AT2G36530
    See related
    Araport:AT2G36530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytosolic enolase; ENO2; ENOC; ENOLASE 2; F1O11.16; F1O11_16; LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2
    Summary
    Involved in light-dependent cold tolerance and encodes an enolase. Protein is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
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    Genomic context

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    See LOS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (15320756..15324129, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene tRNA-Leu Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene haloacid dehalogenase-like hydrolase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtENO2 functions in the development of male gametophytes in Arabidopsis thaliana. Ma X, et al. J Plant Physiol, 2021 Aug. PMID 34102568
    2. ENO2 Affects the Seed Size and Weight by Adjusting Cytokinin Content and Forming ENO2-bZIP75 Complex in Arabidopsis thaliana. Liu Z, et al. Front Plant Sci, 2020. PMID 32983222, Free PMC Article
    3. LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase. Lee H, et al. EMBO J, 2002 Jun 3. PMID 12032082, Free PMC Article
    4. Reduction of the canonical function of a glycolytic enzyme enolase triggers immune responses that further affect metabolism and growth in Arabidopsis. Yang L, et al. Plant Cell, 2022 Apr 26. PMID 34791448, Free PMC Article
    5. ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1. Eremina M, et al. Plant J, 2015 Mar. PMID 25620024

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In addition to an enolase the LOS2/ENO2 locus encodes the transcription factor AtMBP-1, and here we reveal that this bifunctionality serves to maintain the homeostasis of ENO2 activity.
      Title: ENO2 activity is required for the development and reproductive success of plants, and is feedback-repressed by AtMBP-1.
    2. MBP-1-like protein, like tumor suppressor c-myc binding protein, is alternatively translated from full-length LOS2 transcripts using a second start codon.
      Title: AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336601.1
    NM_129209.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Enolase
    NP_181192.1
    • LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2 (LOS2); FUNCTIONS IN: phosphopyruvate hydratase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to salt stress, response to cold, response to light stimulus, response to abscisic acid stimulus; LOCATED IN: in 8 components; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Enolase (InterPro:IPR000941), Enolase, C-terminal (InterPro:IPR020810), Enolase, conserved site (InterPro:IPR020809), Enolase, N-terminal (InterPro:IPR020811); BEST Arabidopsis thaliana protein match is: enolase 1 (TAIR:AT1G74030.1); Has 13396 Blast hits to 13370 proteins in 3710 species: Archae - 270; Bacteria - 5735; Metazoa - 2292; Fungi - 281; Plants - 265; Viruses - 0; Other Eukaryotes - 4553 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15320756..15324129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129209.4 → NP_181192.1  Enolase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25696, Q8RWM8, Q8VYG4, Q940N0
      UniProtKB/TrEMBL
      A0A178VT47, A0A5S9X4J0
      Conserved Domains (1) summary
      PLN00191
      Location:1 → 442
      PLN00191; enolase

    2. NM_001336601.1 → NP_001324936.1  Enolase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1N1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25696.1

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