CUL3 cullin 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CUL3
Official Full Name: cullin 3
Primary source: TAIR:AT1G26830
Locus tag: AT1G26830
See related: Araport:AT1G26830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCUL3; ATCUL3A; CUL3A; cullin 3; cullin 3A; T24P13.25
Summary: Cullin, putative, similar to Cullin homolog 3 (CUL-3) SP:Q13618, GI:3639052 from (Homo sapiens); contains Pfam profile PF00888: Cullin family. Interacts with other components of E3 ligase complex suggesting it functions in RUB-modification. Forms complexes with BTB domain proteins forming a novel class of E3-based ubiquitin protein-ligase complexes. Mutant is early flowering and has a reduced sensitivity to far-red light. cul3a/cul3b homozygous/heterozygous plants are embryo lethal.
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Genomic context

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See CUL3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (9295565..9298629)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CUL3A-LFH1-UBC15 ubiquitin ligase complex mediates SHORT VEGETATIVE PHASE degradation to accelerate flowering at high ambient temperature.
Title: The CUL3A-LFH1-UBC15 ubiquitin ligase complex mediates SHORT VEGETATIVE PHASE degradation to accelerate flowering at high ambient temperature.
Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases.
Title: Regulation of Arabidopsis photoreceptor CRY2 by two distinct E3 ubiquitin ligases.
LFY activity is fully dependent on BOP2 as well as on CUL3A and B to regulate target genes such as APETALA1 and to induce ectopic flower formation.
Title: LEAFY activity is post-transcriptionally regulated by BLADE ON PETIOLE2 and CULLIN3 in Arabidopsis.
This shows that BOP proteins act as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for ubiquitination and subsequent degradation.
Title: BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance.
Data show that CUL3 and BPM proteins assemble in planta with WRI1.
Title: Arabidopsis BPM proteins function as substrate adaptors to a cullin3-based E3 ligase to affect fatty acid metabolism in plants.
The plasma membrane-associated phototropic receptor phot1 is ubiquitinated in response to blue light activation. Ubiquitination of phot1 is dependent upon both the phot1-interacting proteins NPH3 and CUL3.
Title: Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3).
work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells
Title: Arabidopsis CULLIN3 genes regulate primary root growth and patterning by ethylene-dependent and -independent mechanisms.
Arabidopsis CUL3A gene is essential for normal embryogenesis.
Title: Arabidopsis CUL3A and CUL3B genes are essential for normal embryogenesis.
AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [AtCUL3a]
Title: Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family.
CUL3a and CUL3b are essential for plant development [CUL3a]
Title: Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102447.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endosperm development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to red or far red light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
NOT part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
part_of ubiquitin ligase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cullin 3

NP_174005.1

cullin 3 (CUL3); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin homology (InterPro:IPR016158), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin, N-terminal (InterPro:IPR001373), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 3B (TAIR:AT1G69670.1); Has 2310 Blast hits to 2269 proteins in 235 species: Archae - 0; Bacteria - 9; Metazoa - 1034; Fungi - 455; Plants - 372; Viruses - 0; Other Eukaryotes - 440 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

9295565..9298629

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102447.5 → NP_174005.1 cullin 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174005.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WL17, Q7Y1Y8, Q9ZVH4

UniProtKB/TrEMBL

A0A178WM88, A0A5S9VZI7

Conserved Domains (2) summary

pfam00888
Location:29 → 630

Cullin; Cullin family

pfam10557
Location:662 → 721

Cullin_Nedd8; Cullin protein neddylation domain