COR15A cold-regulated 15a [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: COR15A
Official Full Name: cold-regulated 15a
Primary source: TAIR:AT2G42540
Locus tag: AT2G42540
See related: Araport:AT2G42540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtCOR15A; cold-regulated 15a; COR15; F14N22.19; F14N22_19
Summary: A cold-regulated gene whose product is targeted to the chloroplast. Cor15am protects stromal proteins from aggregation under various stress conditions. Constitutive expression increases freezing tolerance in protoplasts in vitro and chloroplasts in vivo. NMR and x-ray diffraction studies suggest that COR15a alters the intrinsic curvature of the inner membrane of chloroplast envelope. Late Embryogenesis abundant protein (LEA). Protects chloroplast membranes during freezing.
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Genomic context

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See COR15A in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (17710441..17712330, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Arabidopsis thaliana mRNA decay factor PAT1 functions in osmotic stress responses and decaps ABA-responsive genes.
Title: The Arabidopsis thaliana mRNA decay factor PAT1 functions in osmotic stress responses and decaps ABA-responsive genes.
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A
Title: Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A.
results suggest the conserved glycine residues are important for maintaining the disordered structure of COR15A but are also compatible with the formation of alpha-helical structure during freezing induced dehydration
Title: Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A.
COR15A-membrane interaction
Title: Intrinsically Disordered Stress Protein COR15A Resides at the Membrane Surface during Dehydration.
we have extended these investigations to two related proteins, LEA11 and LEA25. LEA25 is much longer than LEA11 and COR15A, but shares a conserved central sequence domain with the other two proteins. The C- and N-terminal extensions of LEA25 were important in cryoprotection, as the central domain itself (2H, 4H) only provided a low level of protection.
Title: Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes.
necessary for full cold acclimation; functions in stabilization of chloroplast membranes during freezing through a folding and binding mechanism
Title: Disordered cold regulated15 proteins protect chloroplast membranes during freezing through binding and folding, but do not stabilize chloroplast enzymes in vivo.
GT-4 interacts with TEM2 and then co-regulates the salt responsive gene Cor15A to improve salt stress tolerance.
Title: Trihelix transcription factor GT-4 mediates salt tolerance via interaction with TEM2 in Arabidopsis.
a detailed model for the mode of action of the two COR15 proteins, is reported.
Title: A mechanistic model of COR15 protein function in plant freezing tolerance: integration of structural and functional characteristics.
The results showed that the expression of the exogenous AtCBF3 and AtCOR15A could promote the cold adaptation process to protect eggplant plants from chilling stress.
Title: Heterologous expression of Arabidopsis C-repeat binding factor 3 (AtCBF3) and cold-regulated 15A (AtCOR15A) enhanced chilling tolerance in transgenic eggplant (Solanum melongena L.).
DREB2C functions as transcriptional activator that promotes NaCl tolerance, in part through upregulation of the stress-responsive gene COR15A.
Title: Ectopic expression of an Arabidopsis dehydration-responsive element-binding factor DREB2C improves salt stress tolerance in crucifers.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001202804.1

Supported by ESTs:

NM_180040.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables galactose binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in chaperone-mediated protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cold acclimation	IDA Inferred from Direct Assay more info	PubMed
involved_in cold acclimation	IDA Inferred from Direct Assay more info	PubMed
involved_in cold acclimation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in drought recovery	IDA Inferred from Direct Assay more info	PubMed
involved_in heat acclimation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plastid inner membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein stabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within red or far-red light signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to freezing	IDA Inferred from Direct Assay more info	PubMed
involved_in response to high light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: cold-regulated 15a

NP_001189733.1

cold-regulated 15a (COR15A); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast stroma; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: cold regulated 15b (TAIR:AT2G42530.1).

NP_181782.1

cold-regulated 15a (COR15A); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: cold regulated 15b (TAIR:AT2G42530.1); Has 189 Blast hits to 136 proteins in 40 species: Archae - 0; Bacteria - 9; Metazoa - 3; Fungi - 13; Plants - 155; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).

NP_850371.1

cold-regulated 15a (COR15A); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: in 9 processes; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: cold regulated 15b (TAIR:AT2G42530.1); Has 189 Blast hits to 128 proteins in 40 species: Archae - 0; Bacteria - 9; Metazoa - 3; Fungi - 13; Plants - 155; Viruses - 0; Other Eukaryotes - 9 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

17710441..17712330 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129815.5 → NP_181782.1 cold-regulated 15a [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181782.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IP48, Q42512

UniProtKB/TrEMBL

A0A178VVB5, A0A5S9X6D7, A0A654F192

Conserved Domains (1) summary

cl02879
Location:1 → 59

Chloroa_b-bind; Chlorophyll A-B binding protein
NM_001336986.1 → NP_001323750.1 cold-regulated 15a [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VVB5
NM_001202804.1 → NP_001189733.1 cold-regulated 15a [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189733.1

Status: REVIEWED

UniProtKB/TrEMBL

F4IP47

Conserved Domains (1) summary

cl02879
Location:1 → 47

Chloroa_b-bind; Chlorophyll A-B binding protein
NM_180040.3 → NP_850371.1 cold-regulated 15a [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850371.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VVB5

Conserved Domains (1) summary

cl02879
Location:1 → 47

Chloroa_b-bind; Chlorophyll A-B binding protein