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    ASE1 GLN phosphoribosyl pyrophosphate amidotransferase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816156, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ASE1
    Official Full Name
    GLN phosphoribosyl pyrophosphate amidotransferase 1
    Primary source
    TAIR:AT2G16570
    Locus tag
    AT2G16570
    See related
    Araport:AT2G16570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATASE; ATASE1; GLN phosphoribosyl pyrophosphate amidotransferase 1
    Summary
    Amidophosphoribosyltransferase (ATase: EC 2.4.2.14) is a key enzyme in the pathway of purine nucleotide biosynthesis
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    Genomic context

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    See ASE1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (7180142..7182287, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene pseudo Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene mucin Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two amidophosphoribosyltransferase genes of Arabidopsis thaliana expressed in different organs. Ito T, et al. Plant Mol Biol, 1994 Oct. PMID 7948903
    2. Characterization of Arabidopsis glutamine phosphoribosyl pyrophosphate amidotransferase-deficient mutants. Hung WF, et al. Plant Physiol, 2004 Jul. PMID 15266056, Free PMC Article
    3. Chemical genetic identification of glutamine phosphoribosylpyrophosphate amidotransferase as the target for a novel bleaching herbicide in Arabidopsis. Walsh TA, et al. Plant Physiol, 2007 Jul. PMID 17616508, Free PMC Article
    4. In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis. Narsai R, et al. Plant Physiol, 2011 Nov. PMID 21908688, Free PMC Article
    5. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables amidophosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleobase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plastid HDA PubMed 
    located_in plastid stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GLN phosphoribosyl pyrophosphate amidotransferase 1
    NP_179247.1
    • GLN phosphoribosyl pyrophosphate amidotransferase 1 (ASE1); FUNCTIONS IN: amidophosphoribosyltransferase activity; INVOLVED IN: purine base biosynthetic process, metabolic process; LOCATED IN: cell wall; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase, class-II (InterPro:IPR000583), Phosphoribosyltransferase (InterPro:IPR000836), Amidophosphoribosyl transferase (InterPro:IPR005854), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: GLN phosphoribosyl pyrophosphate amidotransferase 2 (TAIR:AT4G34740.1); Has 21477 Blast hits to 21465 proteins in 2911 species: Archae - 627; Bacteria - 12302; Metazoa - 410; Fungi - 379; Plants - 300; Viruses - 17; Other Eukaryotes - 7442 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7180142..7182287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127208.2 → NP_179247.1  GLN phosphoribosyl pyrophosphate amidotransferase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38999, Q9SI61
      UniProtKB/TrEMBL
      A0A5S9WYG2, A0A654EYF1
      Conserved Domains (1) summary
      PLN02440
      Location:90 → 566
      PLN02440; amidophosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SI61.1

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