HB1 hemoglobin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HB1
Official Full Name: hemoglobin 1
Primary source: TAIR:AT2G16060
Locus tag: AT2G16060
See related: Araport:AT2G16060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHB1; ARATH GLB1; ATGLB1; CLASS I HEMOGLOBIN; F7H1.8; F7H1_8; GLB1; HEMOGLOBIN; hemoglobin 1; NSHB1
Summary: Encodes a class 1 nonsymbiotic hemoglobin induced by low oxygen levels with very high oxygen affinity. It is not likely to be a hemoglobin transporter because of its extremely high affinity for oxygen. Overexpression impairs cold stress-induced nitric oxide (NO) production.
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Genomic context

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See HB1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (6982531..6983777, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The AtHB1 Transcription Factor Controls the miR164-CUC2 Regulatory Node to Modulate Leaf Development.
Title: The AtHB1 Transcription Factor Controls the miR164-CUC2 Regulatory Node to Modulate Leaf Development.
Data suggest that Glbs modulate nitric oxide (NO) and interact with abscisic acid (ABA) in crucial physiological processes such as the plant's response to dessication.
Title: Phytoglobins in the nuclei, cytoplasm and chloroplasts modulate nitric oxide signaling and interact with abscisic acid.
Findings provide evidence supporting the functional implications of the conformational rearrangement found for the distal histidine in AHb1, which mimics the gating role proposed for the same residue in myoglobin.
Title: Histidine E7 dynamics modulates ligand exchange between distal pocket and solvent in AHb1 from Arabidopsis thaliana.
AtHb1 overexpression led to several alterations in transcriptional and metabolic networks, resulting in improved seed yield.
Title: Seed-specific elevation of non-symbiotic hemoglobin AtHb1: beneficial effects and underlying molecular networks in Arabidopsis thaliana.
Rebinding of NO ligands was observed only from site B of AHb1, regardless of conformation.
Title: Ligand migration and binding in nonsymbiotic hemoglobins of Arabidopsis thaliana.
the nature and distribution of internal cavities in the protein matrix
Title: Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana.
Finding strongly supports the idea that AHb1 and AHb2 have distinct physiological functions.
Title: Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana.
The structures of AHb1 and AHb2, modeled on the basis of the homologous rice hemoglobin, exhibit a different cavity system that is fully compatible with the observed ligand binding kinetics
Title: The reactivity with CO of AHb1 and AHb2 from Arabidopsis thaliana is controlled by the distal HisE7 and internal hydrophobic cavities.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_127165.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables oxygen carrier activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within response to hypoxia	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: hemoglobin 1

NP_179204.1

hemoglobin 1 (HB1); FUNCTIONS IN: oxygen binding; INVOLVED IN: response to hypoxia; LOCATED IN: cell wall, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Leghaemoglobin (InterPro:IPR001032), Globin-like (InterPro:IPR009050), Leghaemoglobin, iron-binding site (InterPro:IPR019824), Globin, subset (InterPro:IPR000971), Globin (InterPro:IPR012292); BEST Arabidopsis thaliana protein match is: haemoglobin 2 (TAIR:AT3G10520.1); Has 783 Blast hits to 745 proteins in 194 species: Archae - 0; Bacteria - 173; Metazoa - 274; Fungi - 3; Plants - 318; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

6982531..6983777 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127165.4 → NP_179204.1 hemoglobin 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_179204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O24520

UniProtKB/TrEMBL

A0A178VRG9, A0A384KL50, Q0WSU5

Conserved Domains (1) summary

cd14784
Location:9 → 157

class1_nsHb-like; Class 1 nonsymbiotic hemoglobins and related proteins