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    PAE1 20S proteasome alpha subunit E1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841822, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAE1
    Official Full Name
    20S proteasome alpha subunit E1
    Primary source
    TAIR:AT1G53850
    Locus tag
    AT1G53850
    See related
    Araport:AT1G53850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    20S proteasome alpha subunit E1; 20S PROTEASOME SUBUNIT PAE1; ARABIDOPSIS 20S PROTEASOME ALPHA SUBUNIT E1; ATPAE1; T18A20.8; T18A20_8
    Summary
    Encodes alpha5 subunit of 20s proteosome involved in protein degradation and RNA degradation.
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    Genomic context

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    See PAE1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (20103756..20106077, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pectin methylesterase 2 Neighboring gene pectin methylesterase 1 Neighboring gene Remorin family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 20S proteasome α5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the lettuce mosaic potyvirus HcPro protein. Dielen AS, et al. Mol Plant Pathol, 2011 Feb. PMID 21199564, Free PMC Article
    2. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
    3. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
    4. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
    5. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results extend to A. thaliana alpha(5) the range of HcPro-interacting proteasomal subunits, and suggest that HcPro may modulate its associated RNase activity which may contribute to an antiviral response.
      Title: The 20S proteasome α5 subunit of Arabidopsis thaliana carries an RNase activity and interacts in planta with the lettuce mosaic potyvirus HcPro protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084248.2
    NM_104262.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    20S proteasome alpha subunit E1
    NP_001077717.1
    • 20S proteasome alpha subunit E1 (PAE1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit E2 (TAIR:AT3G14290.1); Has 7954 Blast hits to 7950 proteins in 569 species: Archae - 901; Bacteria - 213; Metazoa - 2759; Fungi - 1863; Plants - 1012; Viruses - 0; Other Eukaryotes - 1206 (source: NCBI BLink).
    NP_175788.1
    • 20S proteasome alpha subunit E1 (PAE1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: response to cadmium ion, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit E2 (TAIR:AT3G14290.1); Has 7954 Blast hits to 7950 proteins in 569 species: Archae - 901; Bacteria - 213; Metazoa - 2759; Fungi - 1863; Plants - 1012; Viruses - 0; Other Eukaryotes - 1206 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20103756..20106077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104262.3 → NP_175788.1  20S proteasome alpha subunit E1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81149, Q56ZL5
      UniProtKB/TrEMBL
      A0A178W977, A0A5S9WRL7, A0A654F8R2
      Conserved Domains (1) summary
      cd03753
      Location:8 → 218
      proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

    2. NM_001084248.2 → NP_001077717.1  20S proteasome alpha subunit E1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81149, Q56ZL5
      UniProtKB/TrEMBL
      A0A178W977, A0A5S9WRL7, A0A654F8R2
      Conserved Domains (1) summary
      cd03753
      Location:8 → 218
      proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81149.1

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