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    Hrd1B RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842812, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Hrd1B
    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT1G65040
    Locus tag
    AT1G65040
    See related
    Araport:AT1G65040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHrd1B; F16G16.3; F16G16_3; homolog of yeast Hrd1
    Summary
    Encodes one of the Arabidopsis homologs of the yeast/human Hrd1 protein: AT3G16090 (Hrd1A), AT1G65040 (Hrd1B). Involved in ERAD (Endoplasmic reticulum-associated degradation).
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    Genomic context

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    See Hrd1B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (24159685..24163669, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene WEB family protein (DUF827) Neighboring gene plasma protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene COMPLEX 1 LYR-like protein Neighboring gene TRAF-like superfamily protein Neighboring gene 4-coumarate:CoA ligase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis. Wu P, et al. Plant Physiol Biochem, 2021 Oct. PMID 34404006
    2. Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Su W, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187394, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
      Title: Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001084305.1
    NM_001334186.1
    NM_001334187.1
    NM_105178.5
    NM_179512.4

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_001077774.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7753 Blast hits to 7726 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2329; Fungi - 701; Plants - 3577; Viruses - 25; Other Eukaryotes - 1121 (source: NCBI BLink).
    NP_176684.4
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7722 Blast hits to 7710 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2325; Fungi - 695; Plants - 3566; Viruses - 25; Other Eukaryotes - 1111 (source: NCBI BLink).
    NP_849843.3
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; LOCATED IN: plasma membrane; EXPRESSED IN: male gametophyte, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING/U-box superfamily protein (TAIR:AT3G16090.1); Has 7762 Blast hits to 7743 proteins in 269 species: Archae - 0; Bacteria - 0; Metazoa - 2332; Fungi - 714; Plants - 3566; Viruses - 25; Other Eukaryotes - 1125 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24159685..24163669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334185.1 → NP_001322004.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKT8, A0A1P8ASM3, A0A5S9WSF5

    2. NM_179512.4 → NP_849843.3  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849843.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3ECI3, Q6NPT7, Q9SS55
      UniProtKB/TrEMBL
      A0A178WKT8, A0A5S9WSF5
      Conserved Domains (2) summary
      COG5243
      Location:9 → 386
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      pfam13639
      Location:291 → 330
      zf-RING_2; Ring finger domain

    3. NM_001084305.1 → NP_001077774.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WKT8, A0A5S9WSF5, B3H675
      Conserved Domains (2) summary
      COG5243
      Location:45 → 315
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      pfam13639
      Location:220 → 259
      zf-RING_2; Ring finger domain

    4. NM_001334186.1 → NP_001322005.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASN3

    5. NM_001334187.1 → NP_001322006.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ASL9

    6. NM_105178.5 → NP_176684.4  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176684.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27GM7
      Conserved Domains (1) summary
      pfam13639
      Location:112 → 151
      zf-RING_2; Ring finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NPT7.1

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