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    NRAMP6 NRAMP metal ion transporter 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838166, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRAMP6
    Official Full Name
    NRAMP metal ion transporter 6
    Primary source
    TAIR:AT1G15960
    Locus tag
    AT1G15960
    See related
    Araport:AT1G15960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNRAMP6; NRAMP metal ion transporter 6; T24D18.6; T24D18_6
    Summary
    member of Nramp2 family
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    Genomic context

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    See NRAMP6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (5481665..5486105, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene ncRNA Neighboring gene cinnamoyl coa reductase 1 Neighboring gene DNA glycosylase superfamily protein Neighboring gene NDH-dependent cyclic electron flow 1 Neighboring gene cyclic nucleotide gated channel 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRAMP6 and NRAMP1 cooperatively regulate root growth and manganese translocation under manganese deficiency in Arabidopsis. Li L, et al. Plant J, 2022 Jun. PMID 35365951
    2. The NRAMP6 metal transporter contributes to cadmium toxicity. Cailliatte R, et al. Biochem J, 2009 Aug 13. PMID 19545236
    3. Plasma membrane-associated calcium signaling modulates cadmium transport. Zhang Y, et al. New Phytol, 2023 Apr. PMID 36567524
    4. Phylogenetic relationships within cation transporter families of Arabidopsis. Mäser P, et al. Plant Physiol, 2001 Aug. PMID 11500563, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasma membrane-associated calcium signaling modulates cadmium transport.
      Title: Plasma membrane-associated calcium signaling modulates cadmium transport.
    2. NRAMP6 functions as an intracellular metal transporter which contributes to the distribution of cadmium within the cell.
      Title: The NRAMP6 metal transporter contributes to cadmium toxicity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_101464.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inorganic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within metal ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to manganese starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NRAMP metal ion transporter 6
    NP_173048.3
    • NRAMP metal ion transporter 6 (NRAMP6); FUNCTIONS IN: inorganic anion transmembrane transporter activity, metal ion transmembrane transporter activity; INVOLVED IN: cellular metal ion homeostasis, metal ion transport; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: LP.06 six leaves visible, LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage, LP.08 eight leaves visible; CONTAINS InterPro DOMAIN/s: Natural resistance-associated macrophage protein (InterPro:IPR001046); BEST Arabidopsis thaliana protein match is: natural resistance-associated macrophage protein 1 (TAIR:AT1G80830.1); Has 5518 Blast hits to 5467 proteins in 1679 species: Archae - 118; Bacteria - 4110; Metazoa - 356; Fungi - 271; Plants - 336; Viruses - 0; Other Eukaryotes - 327 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5481665..5486105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101464.4 → NP_173048.3  NRAMP metal ion transporter 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173048.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84N36, Q9C5V8, Q9S9N8
      UniProtKB/TrEMBL
      A0A5S9UPG8, A0A654EC90
      Conserved Domains (1) summary
      PRK00701
      Location:24 → 446
      PRK00701; divalent metal cation transporter MntH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S9N8.2

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